Tyler Sellers
Published by Tyler Sellers
Fact checked by Donald Christman, BHSc FACT CHECKED
Last updated: December 10, 2020

Glutathione supplements have been growing in popularity over the last few years because of their numerous health-promoting abilities.

This master antioxidant can destroy free radicals that cause oxidative stress, fight inflammation, boost the immune system, detox the liver, support skin health, and more.

Glutathione is naturally produced in your body, but glutathione levels also decrease as you age, thereby making supplementation necessary.

Our team spent the last few months reviewing the best glutathione supplements available on the market.

If you’re still on the fence about which of them you should purchase, this guide might just help you make the right decision.

Read on to see our top recommendations.

Our Top Glutathione Supplements

1 - NOW Glutathione (Editor's Choice)

NOW Glutathione

Free radicals are atoms linked to aging, cell damage, and diseases such as cancer, atherosclerosis, and Alzheimer's disease [1].

Unfortunately, you can’t avoid free radicals. But you can neutralize their harmful effects by supplementing with a “free radical neutralizer” like this glutathione from NOW.

Their Setria (trusted Japanese brand) Glutathione, which comes in a reduced form, may help you achieve a healthy and immune system and aid your body’s detoxification process.

The term reduced doesn’t mean there is less glutathione; it means the glutathione is in its stable, active form, which is when it gets to do its job of working in your cells to neutralize free radicals and other oxidants [2].

Pros
  • Helps reduce inflammation
  • Boosts energy levels and brain function
  • Gives skin a youthful and radiant appearance
  • Good Manufacturing Process (GMP) quality assured
Cons
  • Some users experienced stomach issues while taking this supplement

Other ingredients include milk thistle extract that supports liver health and alpha-lipoic acid (ALA), an element known for its antioxidant properties and ability to scavenge free radicals.

NOW recommends taking one 500 mg capsule per day, preferably on an empty stomach.

2 - Core Med Science Liposomal Glutathione

Core Med science Liposomal Glutathione

Core Med Science Liposomal Glutathione aims to solve the absorption issue that most plain glutathione powders have by using liposomes - microscopic liquid spheres that envelop and protect glutathione to increase its absorption.

This liposomal glutathione relies on this advanced technology to support your liver, brain, and immune function. It also aims to help with concentration, focus, and energy.

If you’re sensitive to the taste of tablets, you’d be glad to know that this supplement comes in easy to swallow soft gel capsules with no taste.

Core Med Science Liposomal Glutathione is also shelf-stable, so there’s no need to refrigerate it.

Like NOW, this brand also uses pure reduced Setria glutathione.

Pros
  • Improves sleep, energy, mood, and focus
  • Uses clean ingredients
  • Glutathione capsules are made from non-GMO sunflower oil
Cons
  • The gel capsules tend to stick together

Each soft gel capsule contains 250 mg of L-Glutathione.

Core Med Science recommends taking 2 gel capsules on an empty stomach per day. You should wait 30-45 minutes before eating or taking other supplements.

3 - Jarrow Formulas Glutathione

Jarrow Formulas

Founded in 1977, Jarrow Formulas is recognized as one of the most reliable providers of science-backed nutritional supplements on the market.

Their OPITAC glutathione (reduced) helps block free radical damage to all types of tissues by bolstering the regeneration of vitamins C & E on your body to their reduced, antioxidant form.

This product is suitable for vegans and vegetarians.

Each capsule holds 500 mg of reduced glutathione. The suggested use is taking one pill per day with a meal.

Pros
  • Also works as an appetite suppressant
  • Improves lung function
  • Gives a significant boost of energy
Cons
  • Might cause headaches

4 - WelEssentials

Wel Essentials

Established in 2009, WelEssentials is relatively new in the nutritional supplements arena, yet their products pack a punch.

Their Reduced Glutathione contains a slew of ingredients meant to maximize the antioxidant properties of glutathione.

N-Acetyl-Cysteine (NAC) and Alpha Lipoic Acid help neutralize free radicals and prevent and repair cell damage.

Organic milk thistle, which contains the antioxidant Silymarin, works to support liver function. Grape seed extract is also added for an extra boost of antioxidants.

It’s also the first glutathione product on this list that contains vitamin C, a component that also helps with detoxification.

This potent formulation promises to give users a stronger immune system function and increased blood glutathione levels.

Pros
  • Helps with focus, concentration, and overall mood
  • Contains complementary ingredients that improve the supplement’s performance
  • Boosts energy and improves sleep
Cons
  • Might cause stomach issues

It’s also vegetarian-friendly and made with organic ingredients.

Each vegetarian capsule has 250 mg of Setria Reduced L-Glutathione. WelEssentials recommends taking two pills per day in the morning.

5 - BulkSupplements Glutathione

BulkSupplements Glutathione

What I like about this L-Glutathione from BulkSupplements is that it comes in a loose powder form, so the possibilities are endless.

You can add it to your smoothie, juice, milk, or just plain water if you’d like to keep it simple. You can also make your own products and capsules using this powder.

This Glutathione Reduced might aid in supporting your liver function and cardiovascular system. The brand says it may also help maintain healthy glucose levels in your body as long as you couple it with a healthy diet and exercise.

BulkSupplements is one of the few manufacturers that have an in-house laboratory where they test their supplements at multiple stages of their production.

Pros
  • Blends easily
  • Helps curb appetite
  • Increases energy for better workouts
Cons
  • Has an unpleasant, overpowering taste

⅕ teaspoon of this powder is equivalent to roughly 500 mg of L-Glutathione. The recommended dosage is one to two ⅕ teaspoons per day.

6 - NusaPure Glutathione

Nusa Pure Glutathione

This is another reduced glutathione that promises to boost antioxidant activity in your body and support your immune system, liver, and cardiovascular health.

NusaPure says their products are made from 100% natural and herbal ingredients. They also avoid using artificial fillers in their supplements.

This glutathione product is non-GMO, gluten-free, all-natural, and vegan and vegetarian-friendly.

Each capsule contains 250 mg of L-Glutathione. The recommended dosage is two

capsules per day, preferably with meals.

Pros
  • Alleviates joint pain
  • Helps with appetite suppression, weight loss, and digestion
  • Improves sleep
Cons
  • Might cause heart palpitations

7 - Fresh Nutrition All Natural Glutathione

Fresh Nutrition all natural Glutathione

Fresh Nutrition’s product range is formulated by a team of nutritionists, making them one of the most trusted manufacturers of natural supplements on the market.

Their All-Natural Glutathione is a free radical scavenger that may help your body detox naturally, support healthy aging, and assist your immune health.

This glutathione supplement is vegan-friendly, non-GMO, gluten-free, soy-free, and contains no artificial flavor, colors, and preservatives.

This product is also manufactured in a cGMP facility in the USA that follows the highest manufacturing standards.

Pros
  • Increases energy levels
  • Improves sleep quality
  • Odorless and easy to swallow
Cons
  • Low dosage of glutathione per capsule compared to others

Each capsule contains 166.6 mg of glutathione. Fresh Nutrition’s recommended dosage is three glutathione capsules per day.

8 - We Like Vitamins Glutathione

We like Vitamins Glutathione

With 200 capsules per bottle that can last you for over three months, I can say this glutathione supplement offers really great value for the price.

We Like Vitamins Glutathione Reduced works by reducing oxidative stress caused by free radicals. It’s also noted for its ability to detoxify the body and support liver, immune system, and cardiovascular health.

Increased glutathione levels have also been shown to provide anti-aging effects, improve skin complexion, and promote healthy nails.

You also get to give back to the community simply by purchasing We Like Vitamins products. The company partnered with Vitamin Angels in 2019 so that every purchase you make will help provide vitamins to women and children in need.

Pros
  • Helps alleviate agitation and fatigue
  • Lower per capsule price
  • Boosts energy
Cons
  • Some users found the smell of this glutathione slightly off-putting

Taking two capsules of this L-glutathione supplement per day will give you 500 mg of glutathione.

9 - aSquared Nutrition Glutathione

aSquared Nutrition Glutathione

Like the previous product, this glutathione supplement contains 200 capsules good for a full 100-day supply.

aSquared’s reduced L-Glutathione may assist in reducing oxidative stress caused by free radicals, lipid peroxides, and heavy metals.

This glutathione may also aid in the detox process of the body, support liver function, promote healthy inflammatory responses, and support heart health.

Aside from its anti-aging properties, this glutathione can also help you achieve healthy skin, nails, and cells.

Pros
  • Gives a great boost of energy
  • Improves sleep quality
  • Helps curb cravings
Cons
  • Might cause stomach issues such as bloating

Each veggie glutathione capsule delivers 250 mg of L-Glutathione. aSquared recommends taking two pills per day.

10 - CCL Advanced Glutathione Spray

ccl advanced Glutathione Spray

This is the only glutathione supplement on this list that comes in liquid form.

CCL Advanced claims their sublingual glutathione spray goes straight into the bloodstream through the membranes of the mouth, which means there is maximum absorption in the body.

It can also increase intracellular levels of glutathione by over 10% within seven hours.

This glutathione may assist in reducing oxidative stress and damage from free radicals.

This product contains glutathione precursors such as ashwagandha, an ancient medicinal herb that can improve brain function, decrease blood sugar and cortisol levels, and help fight symptoms of anxiety and depression [3].

Pros
  • Provides maximum absorption of glutathione
  • Tastes great
  • Boosts energy levels
Cons
  • Proprietary blend makes it impossible to tell how much glutathione you’re getting

It also contains ALA and vitamin C, two components known to enhance the effectiveness of pure glutathione in the body.

The serving size is 12 sprays. However, you can’t really tell how much reduced glutathione you’re getting per spray because of the product’s proprietary blend.

Factors To Consider When Choosing Glutathione Supplements

glutathione supplements

With so many options on the market right now, it can be difficult picking the best glutathione supplement that will work for you.

To help you choose, here are a few factors that I think are worth considering when shopping for a glutathione supplement.

Dosage

pills

To effectively increase the glutathione levels in your body and maximize its benefits, you must first know the appropriate dosage.

If you're taking glutathione for its general health benefits such as recovery from oxidative damage, cellular detoxification, and fighting inflammation, a daily dose of 500 mg to 1000 mg daily should be sufficient.

If you’re taking glutathione for its skin whitening effects, determining the right dosage will require you to examine several factors: your weight, metabolism, general health, etc.

For glutathione to manifest its whitening effects, one must take a double or triple dosage. That’s because it’s the excess glutathione that induces the whitening result.

Here’s a general guide you can use to compute for the right dosage based on your weight:

You must take 20 to 40 mg of glutathione daily per kilogram of body weight and take it once or twice a day for three to six months to see any visible results [4].

For example, if you weigh 65 kg, you should multiply that number by 30 (average of 20 to 40 mg) to get the right dose. That means you would have to consume 1,950 mg of glutathione per day to see any whitening and anti-aging effects.

Note, however, that the above are just general guidelines. It’s still best to consult your physician before taking any supplements. Surely, they would give a better dosage recommendation tailored to your overall health requirements.

Purity

taking pills

Next, check the ingredients list for any additives, fillers, or binders.

Fillers are used to make a product appear more substantial. This means some of the powder you see inside glutathione capsules isn’t the active ingredient; it’s just powder incorporated to “bulk” it up.

This affects the potency of the glutathione supplement, so make sure to always check the label for fillers, so you get the best value for your money.

Binders are used to hold all the ingredients together, so they retain the shape of a tablet. Lactose and sucrose are sometimes used as binders, so keep an eye on those if you're lactose intolerant.

If you are vegan or vegetarian, make sure to check if the company uses plant-based cellulose for their glutathione capsules instead of animal-based gelatin.

While fillers and binders aren’t all unhealthy, I believe that it’s best to avoid glutathione supplements that have them because they affect the purity of the product. And if you’re someone who has food restrictions or allergies, it’s good practice to check the label for these components.

Complementary Ingredients

As mentioned earlier, glutathione works best when it’s in a reduced or active state.

See if the product uses L-Glutathione. If they do, that means the glutathione is in its reduced form and in its working state.

“Glutathione protects cells from oxidants is through recycling of vitamins C and E.”

- Joseph Pizzorno, Naturopathic Physician

Also, if glutathione is supported by ingredients such as N-Acetyl-Cysteine and Alpha Lipoic Acid, that’s a good sign. These two components can potentially enhance the effects of glutathione.

Biologically active compounds like phospholipids can also increase the bioavailability or absorption of glutathione in your body.

Certifications

Nothing gives a consumer peace of mind more than knowing that a supplement has been examined by a third-party entity for safety and quality.

If a glutathione product is GMP-certified, that means its manufacturing process has been verified as safe and adherent to the highest quality standards.

FAQs

What Are the Bad Side Effects of Glutathione?

There is little research discussing the potential side effects of taking glutathione.

However, there is some concern about glutathione supplementation triggering stomach issues such as cramping and bloating. Some people may also have allergic reactions to glutathione and develop rashes while taking it [5].

Taking glutathione long-term has also been linked to lower zinc levels [6].

Can I Take Glutathione and Vitamin C Together?

Yes, you can take glutathione and vitamin C together. It is highly recommended.

Studies show that Vit C may increase glutathione levels by attacking free radicals first, thereby sparing glutathione. It also converts oxidized glutathione back into its active form.

Is Glutathione whitening permanent?

No, glutathione whitening is not permanent.

Whether administered orally or intravenously, you must keep on taking glutathione to sustain its whitening effects.

What Is The Best Glutathione Supplement?

NOW Glutathione came out as the most superior glutathione supplement out of all the products we reviewed.

First, the company uses glutathione in its reduced form, which means it gets to do its job of neutralizing free radicals and preventing oxidative damage more effectively.

The supplement also contains alpha-lipoic acid and milk thistle extract - two components known for increasing the efficacy of glutathione.

The ingredients don’t include any animal byproducts, and the capsules are made of cellulose, so this supplement is suitable for both vegans and vegetarians.

All NOW products are also GMP certified, which means every step of their manufacturing process has been examined by a trusted third-party authority.

Given all of the above, we believe that NOW Glutathione might be the best glutathione supplement on the market today.

NOW Glutathione

NOW Glutathione

Our #1 Recommendation

  • Helps reduce inflammation
  • Boosts energy levels and brain function
  • Gives skin a youthful and radiant appearance
  • Good Manufacturing Process (GMP) quality assured
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About the author

  • I’ve tried your #1 and #3 recommendation and I liked PhenQ more because I lost more weight. These pills are definitely the best thermogenic fat burner for men (not sure for the ladies tho)

  • I immediately purchased one of the products highlighted by Isaac. Since then, I have been taking for a week now. I never usually take any of this kind of pills for anything, but I wanted to shed a few pounds that I have gained over this quarantine period which has been hard to get off and it is pissing me off. I’m taking two pills twice a day. I don’t know if it’s just me, but I do feel and notice an immediate boost in energy and a little parched. So, make sure you stay hydrated with this when taking this. Also I ride my bike at least 3 times a week and it would take me about 45 min in before I start sweating before I started using this. Now with the pills, I am totally drenched in sweat 15 min into my activity. So evidently something extra must have been working on with me. I don’t know if this is the pill or not, but I find myself eating less and not snacking as much. I can’t even finish 1 plate of food anymore. My body does feel like it is changing, and I can already see a little difference from now even after just a couple of weeks. I will keep taking and hope for the best. Overall, I am glad I listened to Isaac about his thoughts. Please do listen to him as well.

  • Before I will start, I would like to extend my gratitude for the effort Isaac has been putting to help us with our decisions. Thank you, man. Now, let me tell you what I have experienced. Actually, this product is pretty amazing!!! A big disclaimer is if you put in the work. As I have noticed, it decreases my appetite so I’ve found that I only eat about half portions at meal times. I eat kind of healthy to begin with but I do not stick to a strict or specific diet as some of you may have been doing. I purchased this not a few while back and started using it immediately after preparing my needs. It gave me energy to do extensive physical activities, and even just do simple household tasks which we all men avoid to do. When I started, I initially weighed in around 160 pounds. I had previously been prescribed with another product by a friend but I was looking for something that fits my budget. I wanted to lose 10 more pounds and figured I could do so with a bottle of this. Just this morning, I weighed myself and I am 150.2. To be honest, I don’t work out every day since I am busy with work, but this has really controlled my appetite which has always been my biggest issue. So my advice is for people out there is listen to what Isaac say. He truly knows what he is sharing and people must try it! It’s at a great value to try it out because it really helped me deal with losing that last stubborn few pounds. Thankful for Isaac. Let’s keep on losing those unwanted pounds!

  • One of these product works and I’m glad I stumbled upon your post before actually purchasing one! But, it would be unfair for the product if it works and you are no doing your part. So you also have to do your part. What I am trying to say is this. I’m a huge snacker every afternoon. So at noontime I take 2 pills. It holds me over til dinner. Simple as that! I’m up before the sun rises every day. I have would take the usual breakfast. Before lunchtime, I have to eat a nice size lunch. Then by noontime, I pop 2 of these pills and these pills will take me until the sun sets. When the night comes, I eat dinner. Done and that’s my usual routine. What may have worked for me may not necessarily work for you. So you have to figure out for yourselves the right time to take these pills and you’ll see results! Thanks Sir Robertson. I am a huge fan of yours.

  • At first I was unsure about this product but when I started doing my research, I ended up in Isaac’s post. I have been trusting him for my decisions when it comes to this thing. I got encouraged to order some right away and believe it or not, that was the last money I had left on my debit card. But I wanted to try this product so much that I said why not plus the words came from your trusted writer Isaac who had a lot to do with me making up my mind whether I was going to try this product or not. When I finally ordered it, I couldn’t wait to get it. When I received it, I started using it immediately and I started seeing results immediately. I am a part of a gym so I’m working out as well. the stubborn pounds are just melting off like sweat. It’s like someone put it in a pot and it just melted away like magic. I am glad I listened. Thanks Isaac.

  • I’ve just started using this product when I found out that Sir Isaac has done and posted his thoughts on these. As soon as I began, I have noticed a significant reduction in my appetite. I’m usually someone who has constant cravings that are uncontrollable – not just simple hunger, but that pregnancy-strength cravings similar to what my wife has experienced when she was pregnant. Those cravings that can only be satisfied with whichever specific food. With this product, I’ve found that I’m much more in control of what I actually put in my mouth, not just how much, and it’s really helped me stick to my goals. I also have really appreciated the professionalism of Isaac in the way he conveys his thoughts. It’s clear that he genuinely cares about his avid readers’ experience. 10/10 will purchase again when I am out of stock. Thanks!

  • I have always been skeptical of these kinds of products. I have researched so much throughout the years on many brands and products. I finally decided to give this brand and formula a shot since Isaac has been my trusted writer over the years. When I tried it, actually it works. I started out with one pill as recommended for about a week, then been doing 2 since then. I’ve lost about 10 pounds, and I’m still using the product now as of writing. I would recommend these if you’re looking for a true pill that works like magic. I wasn’t sure if it would work, but it does, and I’m glad I bought them. Thanks for encouraging me Isaac. I am a more invested reader starting now.

  • First of all, thank you Isaac for the thorough list. I tried this because the I have been his reader since who knows when. Also I’m the father of the bride in 3 weeks with a hundred things to prepare for and lots of pictures to pose for soon. This product is amazing. I’m only on day 2 and will keep you guys posted in a month if I remember to write it. Day 1 was unreal. I had no idea I could feel so alert, able to make quicker decisions that have been hard planning a wedding. My house hasn’t been this clean in a while and I had energy all day to clean it. My mood was better than it’s been in a long time. While I’m certainly not an expert in this area, I’m so glad to feel the benefits of this on day 1 taking one pill twice a day. I can feel the appetite suppressant working however I’m more happy about the mood boost and energy at this time. If your hesitant to try a product like this, I can say this is worth a try for everything it says! Plus Isaac has written it out so there is nothing to worry really. I’m looking forward to seeing more results after a month on this product.

  • I have seen several negative posts about these products however I did not believe them knowing that Isaac is my most trusted writer when it comes to this topic. After buying it, I immediately took it up. It works fine to me and lost 15 pounds already in a month. Of course, you also have to do your part. Try not to eat anything that’s white like bread, rice, and flour. Also drink greens such as blend, shake or smoothies whichever works for you. For dinner, I eat salad. Most important is that you eat right. If you are full then don’t eat until your tummy tells you to eat something. Take a pill when you wake up, drink greens for lunch then have healthy meal for dinner. You cannot just take a pill and not doing anything or eat all you want to. This WILL NOT help you lose weight!!!

  • I don’t normally use products or dietary pills but when weight keeps you from doing what you want you’ll find any means to change that. Initially, I started using this product to help my metabolism in conjunction with going to the gym and only a few weeks after I started I’ve already lost 8 pounds. If this product didn’t work for me then I wouldn’t leave a comment like this. But it does. So if you’re considering a product that will help you shed off those pounds, this is what I would consider a tried and true product you should consider purchasing. Thank you Isaac. I am new to your blog but I am glad I listened to your loyal readers.

  • Will try this product and leave a review in 1 month. I tend to gain and lose fat very fast so this should be interesting.