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Glutathione supplements have been growing in popularity over the last few years because of their numerous health-promoting abilities.
This master antioxidant can destroy free radicals that cause oxidative stress, fight inflammation, boost the immune system, detox the liver, support skin health, and more.
Glutathione is naturally produced in your body, but glutathione levels also decrease as you age, thereby making supplementation necessary.
Our team spent the last few months reviewing the best glutathione supplements available on the market.
If you’re still on the fence about which of them you should purchase, this guide might just help you make the right decision.
The Best Glutathione Supplements
- Best Overall Glutathione Supplement: RKMD OGF
- Cheapest Glutathione Supplement: NusaPure Glutathione
- Best Active Glutathione Formula: NOW Glutathione
- Best Glutathione Formula for Energy: RKMD OGF
- Best Non-GMO Glutathione Capsules: Core Med Science
- Best Vegan Gluthatione Supplement: Jarrow Formulas
Our Top Glutathione Picks (April 2024)
1 - RKMD Original Glutathione Formula (Best Overall & for Energy)
Pros and Cons
Pros
- Increases energy levels naturally
- Helps fight inflammation
- Boosts glutathione levels in a short timespan
Cons
- RKMD suggests taking 6 pills every morning. However, some individuals may have to work up from 2 pills daily to the full dose.
Based on our tests, this glutathione supplement uses an exclusive formula that is different from the rest of the supplements on the market.
RKMD Original Glutathione Formula claims to be made up of L-glutamine and N-acetyl cysteine (NAC) which helps replenish glutathione naturally in your body.
The supplement also activates the Nrf2 protein, signaling the body to make glutathione while simultaneously providing the essential chemicals your body needs to make the substance.
OGF acts as an antioxidant and an antitoxin, helps enhance the immune system, and helps fight aging. It also improves cellular function, leading to improved brain activity, skin health, and internal organ function, such as liver health.
We loved the fact that this best glutathione supplement doesn’t contain any fillers, additives, or artificial ingredients that could possibly interfere with the efficacy of your supplement.
2 - NOW Glutathione (Best Active Glutathione)
Pros and Cons
Pros
- Helps reduce inflammation
- Boosts energy levels and brain function
- Gives skin a youthful and radiant appearance
- Good Manufacturing Process (GMP) quality assured
Cons
- Some users experienced stomach issues while taking this supplement
According to an article found on the LiveScience website, free radicals are atoms linked to aging, cell damage, and diseases such as cancer, atherosclerosis, and Alzheimer's disease [1].
Unfortunately, you can’t avoid free radicals. But you can neutralize their harmful effects by supplementing with a “free radical neutralizer” like this glutathione from NOW.
Their Setria (trusted Japanese brand) Glutathione, which comes in a reduced form, may help you achieve a healthy immune system.
Our tests indicate that it can also aid your body’s detoxification process.
According to an article found on Ask The Scientists website, the term reduced doesn’t mean there is less glutathione; it means the glutathione is in its stable, active form, which is when it gets to do its job of working in your cells to neutralize free radicals and other oxidants [2].
Other ingredients in this glutathione supplement include milk thistle extract, which supports liver health, and alpha-lipoic acid (ALA).
3 - Jarrow Formulas Glutathione (Best Vegan)
Pros and Cons
Pros
- Also works as an appetite suppressant
- Improves lung function
- Gives a significant boost of energy
Cons
- Might cause headaches
Founded in 1977, Jarrow Formulas is recognized as one of the most reliable providers of science-backed nutritional supplements on the market.
Their OPITAC glutathione supplement (reduced) helps block free radical damage to all types of tissues by bolstering the regeneration of vitamins C & E in your body to their reduced, antioxidant form.
Our team also found that the product is suitable for vegans and vegetarians.
Each capsule holds 500 mg of reduced glutathione. The suggested use is to take one pill per day with a meal.
4 - Core Med Science Liposomal Glutathione (Best Non-GMO)
Pros and Cons
Pros
- Improves sleep, energy, mood, and focus
- Uses clean ingredients
- Glutathione capsules are made from non-GMO sunflower oil
Cons
- The gel capsules tend to stick together
Core Med Science Liposomal Glutathione aims to solve the absorption issue that most plain glutathione powders have by using liposomes—microscopic liquid spheres that envelop and protect glutathione—to increase its absorption.
This liposomal glutathione supplement relies on this advanced technology to support your liver, brain, and immune function. It also aims to help with concentration, focus, and energy.
If you’re sensitive to the taste of tablets, you’d be glad to know that this liposomal glutathione supplement comes in easy-to-swallow soft gel capsules with no taste.
We also appreciate that the Core Med Science Liposomal Glutathione supplement is shelf-stable, so there’s no need to refrigerate it.
Each soft gel capsule contains 250 mg of L-glutathione.
5 - BulkSupplements Glutathione
Pros and Cons
Pros
- Blends easily
- Helps curb appetite
- Increases energy for better workouts
Cons
- Has an unpleasant, overpowering taste
What I like about this L-Glutathione from BulkSupplements is that it comes in a loose powder form, so the possibilities are endless.
You can add this glutathione supplement to your smoothie, juice, milk, or just plain water if you’d like to keep it simple. You can also make your own products and capsules using this powder.
This glutathione reduction might aid in supporting your liver function and cardiovascular system. The brand says it may also help maintain healthy glucose levels in your body as long as you couple it with a healthy diet and exercise.
BulkSupplements is one of the few manufacturers that has an in-house laboratory where they test their glutathione supplements at multiple stages of their production.
6 - NusaPure Glutathione (Cheapest)
Pros and Cons
Pros
- Alleviates joint pain
- Helps with appetite suppression, weight loss, and digestion
- Improves sleep
Cons
- Might cause heart palpitations
This is another reduced glutathione supplement that promises to boost antioxidant activity in your body and support your immune system, liver, and cardiovascular health.
NusaPure says its products are made from 100% natural and herbal ingredients. They also avoid using artificial fillers in their supplements.
What I like about this glutathione supplement is that it’s non-GMO, gluten-free, all-natural, vegan, and vegetarian-friendly.
Each capsule contains 250 mg of L-glutathione.
7 - Fresh Nutrition All Natural Glutathione
Pros and Cons
Pros
- Increases energy levels
- Improves sleep quality
- Odorless and easy to swallow
Cons
- Low dosage of glutathione per capsule compared to others
Fresh Nutrition’s product range is formulated by a team of nutritionists, making them one of the most trusted manufacturers of natural supplements on the market.
We appreciate that their all-natural glutathione supplement is a free radical scavenger that may help your body detox naturally, support healthy aging, and assist your immune health.
This glutathione supplement is vegan-friendly, non-GMO, gluten-free, and soy-free.
This product is also manufactured in a cGMP facility in the USA that follows the highest manufacturing standards.
Each capsule contains 166.6 mg of glutathione.
8 - WelEssentials
Pros and Cons
Pros
- Helps with focus, concentration, and overall mood
- Contains complementary ingredients that improve the supplement’s performance
- Boosts energy and improves sleep
Cons
- Might cause stomach issues
Established in 2009, WelEssentials is relatively new in the nutritional supplement arena, yet its products pack a punch.
Their reduced glutathione supplement contains a slew of ingredients meant to maximize the antioxidant properties of glutathione.
N-acetyl cysteine (NAC) and alpha-lipoic acid help neutralize free radicals and prevent and repair cell damage.
Organic milk thistle, which contains the antioxidant Silymarin, works to support liver function. Grape seed extract is also added for an extra boost of antioxidants.
It's also the first glutathione supplement product on this list that contains vitamin C, a component that we've always appreciated and that helps us detoxify.
Each vegetarian capsule has 250 mg of Setria-reduced L-glutathione. WelEssentials recommends taking two pills per day in the morning.
9 - We Like Vitamins Glutathione
Pros and Cons
Pros
- Helps alleviate agitation and fatigue
- Lower per capsule price
- Boosts energy
Cons
- Some users found the smell of this glutathione slightly off-putting
With 200 capsules per bottle that can last you for over three months, I can say this glutathione supplement offers really great value for the price.
We Like Vitamins Glutathione reduction works by reducing oxidative stress caused by free radicals. It’s also noted for its ability to detoxify the body and support the liver, immune system, and cardiovascular health.
Increased glutathione levels have also been shown to provide anti-aging effects, improve skin complexion, and promote healthy nails.
The company partnered with Vitamin Angels in 2019 so that every glutathione supplement purchase you make will help provide vitamins to women and children in need.
Taking two capsules of this L-glutathione supplement per day will give you 500 mg of glutathione.
10 - aSquared Nutrition Glutathione
Pros and Cons
Pros
- Gives a great boost of energy
- Improves sleep quality
- Helps curb cravings
Cons
- Might cause stomach issues such as bloating
Like the previous product, this glutathione supplement contains 200 capsules, good for a full 100-day supply.
Reduced L-Glutathione from aSquared’s may assist in reducing oxidative stress caused by free radicals, lipid peroxides, and heavy metals.
This glutathione supplementation may also aid in the detoxification process of the body, support liver function, promote healthy inflammatory responses, and support heart health.
Aside from its anti-aging properties, this glutathione can also help you achieve healthy skin, nails, and cells.
Each veggie glutathione capsule delivers 250 mg of L-glutathione.
11 - CCL Advanced Glutathione Spray
Pros and Cons
Pros
- Provides maximum absorption of glutathione
- Tastes great
- Boosts energy levels
Cons
- Proprietary blend makes it impossible to tell how much glutathione you’re getting
This is the only glutathione supplement on this list that comes in liquid form.
CCL Advanced claims their sublingual glutathione spray goes straight into the bloodstream through the membranes of the mouth, which means there is maximum absorption in the body.
We liked the fact that it can also increase intracellular levels of glutathione by over 10% within seven hours.
This product contains glutathione precursors such as ashwagandha, an ancient medicinal herb that can improve brain function, decrease blood sugar and cortisol levels, and help fight symptoms of anxiety and depression [3].
The serving size is 12 sprays. However, you can’t really tell how much reduced glutathione you’re getting per spray because of the product’s proprietary blend.
How We Tested These Supplements
As a health and performance coach, I understand the importance of choosing the right supplements to support overall well-being and performance.
In testing the best glutathione supplements, I employed a comprehensive approach, focusing on ingredients, effectiveness, price, and additional criteria based on extensive research and personal experience.
Ingredients
The quality and type of glutathione used in the supplements were my primary focus.
I examined whether the supplements contained reduced L-glutathione, the most bioavailable form, and checked for the presence of any beneficial supporting ingredients like Vitamin C or alpha-lipoic acid, which can enhance glutathione absorption and efficacy.
The absence of harmful fillers, artificial colors, or preservatives was also a key factor in my assessment.
Effectiveness
To evaluate effectiveness, I not only used these supplements myself but also gathered feedback from clients who had incorporated them into their health regimes.
I monitored for noticeable improvements in areas typically associated with glutathione supplementation, such as enhanced detoxification, improved skin health, and overall energy levels.
Any clinical studies or research supporting the effectiveness of the specific formulations were also taken into account.
Price
Price comparison was essential to determine the value offered by each supplement. I compared the cost relative to the dosage, ingredient quality, and the number of servings per package.
This helped in assessing whether the supplements were competitively priced and offered good value for money.
Bioavailability
Glutathione's effectiveness largely depends on its bioavailability.
I evaluated the form of glutathione used in the supplements and any additional ingredients that might enhance its absorption and utilization in the body.
Manufacturing Standards and Quality Control
The manufacturing process and quality control measures of the supplement brands were scrutinized.
I looked for products manufactured in facilities that adhere to Good Manufacturing Practices (GMP) and those that underwent rigorous quality control and testing.
User Reviews and Testimonials
To broaden the scope of the evaluation, I analyzed user reviews and testimonials.
This provided insights into the experiences of a wider range of users, highlighting common benefits and any potential issues with the supplements.
Glutathione Buyer's Guide
With so many options on the market right now, it can be difficult picking the best glutathione supplement that will work for you.
To help you choose, here are a few factors that I think are worth considering when shopping for the best glutathione supplement.
Dosage
To effectively increase the glutathione production levels in your body and maximize its benefits, you must first know the appropriate dosage.
For glutathione to manifest its whitening effects, one must take a double or triple dosage. That’s because it’s the excess glutathione that induces the whitening result.
Here’s a general guide you can use to compute for the right dosage based on your weight:
You must take 20 to 40 mg of glutathione daily per kilogram of body weight and take it once or twice a day for three to six months to see any visible results, according to the Journal of Clinical & Experimental Dermatology Research [4].
For example, if you weigh 65 kg, you should multiply that number by 30 (average of 20 to 40 mg) to get the right dose. That means you would have to consume 1,950 mg of glutathione per day to see any whitening and anti-aging effects.
Purity
Next, check the ingredients list for any additives, fillers, or binders.
Fillers are used to make a product appear more substantial. This means some of the powder you see inside glutathione capsules isn’t the active ingredient; it’s just powder incorporated to “bulk” it up.
Binders are used to hold all the ingredients together, so they retain the shape of a tablet. Lactose and sucrose are sometimes used as binders, so keep an eye on those if you're lactose intolerant.
If you are vegan or vegetarian, make sure to check if the company uses plant-based cellulose for their glutathione capsules instead of animal-based gelatin.
Complementary Ingredients
As mentioned earlier, glutathione works best when it’s in a reduced or active state.
See if the product uses L-Glutathione. If they do, that means the glutathione is in its reduced form and in its working state.
“Glutathione protects cells from oxidants through recycling of vitamins C and E.”
- Joseph Pizzorno, Naturopathic Physician
Also, if glutathione is supported by ingredients such as N-Acetyl-Cysteine and Alpha Lipoic Acid, that’s a good sign. These two components can potentially enhance the effects of glutathione.
Biologically active compounds like phospholipids can also increase the bioavailability or absorption of glutathione in your body.
Certifications
Nothing gives a consumer peace of mind more than knowing that a supplement has been examined by a third-party entity for safety and quality.
If a glutathione supplement product is GMP-certified, that means its manufacturing process has been verified as safe and adherent to the highest quality standards.
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FAQs
What Are the Bad Side Effects of Glutathione?
The bad side effects of taking glutathione are still not researched enough. However, there is some concern about glutathione supplementation triggering stomach issues such as cramping and bloating. Some people may also have allergic reactions to glutathione and develop rashes while taking it [5]. Taking glutathione supplements long-term has also been linked to lower zinc levels [6].
Can I Take Glutathione and Vitamin C Together?
Yes, you can take glutathione and vitamin C together. It is highly recommended. Studies show that Vit C may increase glutathione levels by attacking free radicals first, thereby sparing glutathione. It also converts oxidized glutathione back into its active form.
Is Glutathione Whitening Permanent?
No, glutathione whitening is not permanent. Whether administered orally or intravenously, you must keep on taking the best glutathione supplements to sustain its whitening effects.
What Is the Historical Significance of Glutathione in Human Health?
Glutathione, known as the "master antioxidant," was discovered in 1888 by J. de Rey-Pailhade. Initially identified in yeast cells, its crucial role in human health, particularly in detoxification, immune response, and cellular protection against oxidative stress, wasn't fully understood until the 20th century. This historical journey highlights its enduring importance in health and wellness.
What Are Natural Sources of Glutathione, and How Do They Compare to Supplements?
Natural sources of glutathione include avocados, spinach, asparagus, garlic, and Brussels sprouts. Incorporating these foods into your diet can naturally enhance your body's glutathione reserves. While these foods can boost glutathione levels, supplements provide a consistent and measurable dose, offering a more direct way to increase glutathione levels in the body.
How Does Glutathione Benefit the Skin, and What Are the Safety Considerations?
Glutathione benefits the skin by detoxifying, potentially lightening the skin by inhibiting melanin production and reducing the appearance of wrinkles and fine lines. However, it's essential to be aware of potential interactions and contraindications, especially if you are on medication, pregnant, breastfeeding, or have a medical condition like liver or kidney issues. Consulting with a healthcare professional is crucial to ensure the safe and effective use of glutathione supplements.
Final Verdict: Our Recommended Glutathione Supplement
Out of all the products we reviewed, we liked RKMD Original Glutathione Formula the best.
The product uses a unique formula featuring scientifically proven ingredients that replenish glutathione in your body naturally.
OGF activates the Nrf2 protein that prompts your body to produce glutathione while also supplying the essential chemicals you need to make this substance.
It also delivers antioxidant and antitoxin effects that strengthen the immune system, combat aging, and improve organ function, making it an all-in-one supplement.
Our #1 Recommendation
RKMD Original Glutathione Formula (Best Overall & for Energy)
Rated With Total Shape's Scoring System
- Increases energy levels naturally
- Helps fight inflammation
- Boosts glutathione levels in a short timespan
- RKMD suggests taking 6 pills every morning. However, some individuals may have to work up from 2 pills daily to the full dose.
About The Author
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It’s so hard to tell which one is effective glutathione since they’re mass-produced nowadays.
Lots of choices here, but as for me, I’ve been using Now Glutathione and it’s the best glutathione brand for me.