12 Best NAD+ Supplements (2024): A BioHacker's Perspective

Supplements Considered 36
Supplements
Considered
Hours of Research 109
Hours
of Research
Reviews Examined 84
Reviews
Examined
Experts Interviewed 15
Experts
Interviewed
James Cunningham, BSc, CPT
Published by James Cunningham, BSc, CPT | Staff Writer & Senior Coach
Last updated: June 20, 2024
FACT CHECKED by Dr. Kristy Dayanan, BS, MD
We personally test every product featured in our reviews and guides. By ordering products anonymously and getting a group of independent testers, we are able to get first-hand experience and provide data-driven recommendations. Learn more.

Looking to boost your vitality and extend your healthy years? NAD+ supplements offer a promising path forward.

While numerous studies highlight the role of these supplements in DNA repair and promoting longevity, my personal journey led me to delve deeper into their immediate impact on vitality and vigor.

We teamed up with a few clients to test some of the best NAD supplements. Over a three-month period, we observed and noted changes in energy levels, cognitive function, and sleep quality.

Continue reading to uncover the ideal NAD supplement for promoting healthy aging.

The Best NAD+ Supplements

Editor's Choice
Wonderfeel® Youngr™
Wonderfeel
Rated 4.8/5
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2nd Best Choice
Tru Niagen®
Tru Niagen
Rated 4.7/5
Click For Best Price
3rd Best Choice
Invity NAD+ Booster Energy
Invity
Rated 4.6/5
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Our Reviewed NAD+ Supplements (June 2024)

1 - Wonderfeel® Youngr™ (Best Overall)

Rated 4.8/5
4.9
Ingredients
4.8
Price
4.7
User Ratings
4.9
Product Effectiveness
4.8
Dosage
4.9
Purity
Wonderfeel® Youngr™
  • Price per serving : $1.49
  • Key ingredients : NMN, Resveratrol
  • Form : Capsule
  • Third-party tested : Yes

Pros and Cons

Pros

  • Supports recovery after long days
  • Aids in aerobic activities
  • Reasonably priced

Cons

  • The 900 mg dose may be too much for certain people

Who is it for?

Who is it for?

  • • People needing increased cellular energy
  • • Those seeking anti-aging benefits

Who is it not for?

  • • Those sensitive to high NMN doses

Final Verdict

Highly effective in boosting energy and delaying cellular aging. Suitable for most, but dosage needs attention.

After a month of taking Wonderfeel, which delivers 900 mg NMN (nicotinamide mononucleotide), I can personally vouch for its efficacy in bolstering cellular energy metabolism and its potential to decelerate cellular aging.

The amount of NMN in this supplement is effective in promoting cellular health, raising energy levels, and reducing sleep problems and is backed by the latest human clinical trials.

Wonderfeel nicotinamide adenine dinucleotide dietary supplement is crafted in the USA in GMP-compliant facilities to ensure maximum quality.

In addition, it contains no preservatives, is non-GMO and vegan-friendly, and is free of gluten, dairy, fish, and soy.

Some clinical trials have indicated a potential increase in athletic performance among elderly participants using this supplement.

Amount: 

Compared to Tru Niagen® and Thorne Research ResveraCel, a daily dose of Wonderfeel has a bigger impact on your focus and clarity.

2 - Tru Niagen® (Best Brand Recognition)

Rated 4.7/5
4.8
Ingredients
4.6
Price
4.7
User Ratings
4.7
Product Effectiveness
4.7
Dosage
4.8
Purity
Tru Niagen®
  • Price per serving : $1.25
  • Key ingredients : Nicotinamide Riboside
  • Form : Capsule
  • Third-party tested : Yes

Pros and Cons

Pros

  • Claims to help reduce metabolic stressors
  • The formula was chosen based on results from human clinical trials
  • Positive reviews about effects kicking in after two weeks
  • Available with great subscription discounts

Cons

  • The anti-aging effects may take longer to become visible

Who is it for?

Who is it for?

  • • People needing quick energy boost
  • • Those seeking a reputable brand

Who is it not for?

  • • Those expecting immediate anti-aging results

Final Verdict

Recommended for its brand recognition and scientific support, with noticeable benefits. Ideal for most users, especially beginners.

Tru Niagen®, a renowned nicotinamide riboside supplement, stood out not just because of its brand name but genuinely due to the palpable results I experienced. The specific source and type of nicotinamide were chosen based on scientific trials that showed positive results.

It contains 300 mg of nicotinamide riboside from Niagen®, a patented form of nicotinamide riboside NR that supports energy production and cellular function. It has the approval of FDA-approved scientific research as well.

With this, it claims to support cellular function and metabolism, increase cellular energy production, promote cellular repair, and defend cells against metabolic stresses in order to maintain overall health status. It applies whether your current goal is weight gain or weight loss.

Check out our full Tru Niagen review.

Amount: 

Our research and editorial team observed significant health improvements in our clients' energy metabolism and immune systems in as little as two weeks of regular NAD supplements, which makes it one of the faster-acting supplements.

This supplement also has a 150 mg version where you can take two capsules separately throughout the day to meet the recommended 300 mg daily dosage.

The only thing you might not notice immediately is the effect on the physical aging as this could take several months.

3 - Invity NAD+ Booster Energy (Best for Energy Boost)

Rated 4.6/5
4.7
Ingredients
4.6
Price
4.6
User Ratings
4.6
Product Effectiveness
4.6
Dosage
4.7
Purity
Invity NAD+ Booster Energy
  • Price per serving : $1.50
  • Key ingredients : NMN, TMG
  • Form : Capsule
  • Third-party tested : Yes

Pros and Cons

Pros

  • Comes in a natural orange flavor that isn’t overpowering
  • Added vitamins for boosted mental and physical energy
  • The powder mixes easily with water and comes in convenient sachets

Cons

  • Only available in packs of 15

Who is it for?

Who is it for?

  • • People needing quick energy boost
  • • Those needing a convenient supplement

Who is it not for?

  • • Those who dislike orange flavor

Final Verdict

Excels in energy boosting and convenience. Suitable for busy professionals and those needing quick energy.

Invity is a brand I’ve not only recommended but also incorporated into my own regimen. The firsthand benefits I’ve reaped align with the positive feedback from my clients, underscoring its effectiveness.

A number of my clients reported feeling more energized throughout the day after using it, substantiating.

What sets it apart is its convenient sachets with an exact dose of powder for cellular support and natural energy production. These have been game changers, according to my clients, especially when they need a quick boost to support cellular energy during long work hours.

That makes it easy to put it in your bag and take it later in the day at work for a mental boost.

Our experience also showed that the powder mixes fast with water into a tasty and refreshing drink. The orange flavor is completely natural, and it’s not over-sweetened to mask artificial flavors.

There’s also a long list of B vitamins included, which should have a positive effect on your overall energy levels as well. Our testing did confirm that we felt more energized for longer parts of the day.

Amount: 

4 - aSquared Nutrition Nicotinamide with Resveratrol (Cheapest Option)

Rated 4.6/5
4.6
Ingredients
4.9
Price
4.5
User Ratings
4.6
Product Effectiveness
4.5
Dosage
4.6
Purity
eSquared Nutrition Nicotinamide with Resveratrol
  • Price per serving : $0.23
  • Key ingredients : Nicotinamide, Resveratrol
  • Form : Capsule
  • Third-party tested : Yes

Pros and Cons

Pros

  • Might help boost your energy levels and immune system
  • Claims to be a flush-free product to avoid side effects
  • Seems to provide healthy aging and anti-inflammatory properties

Cons

  • Resveratrol is not suitable for people undergoing blood-thinning medication

Who is it for?

Who is it for?

  • • Budget-conscious individuals
  • • Those needing a side-effect-free product

Who is it not for?

  • • People on blood-thinning medication

Final Verdict

High cost-effectiveness and side-effect-free, suitable for most users. Affordable but watch for drug interactions.

We thought this supplement had a clever name. If you’re a science nerd, you might notice the hint at Einstein's formula.

This supplement offers a unique blend of 500 mg of nicotinamide and 100 mg of resveratrol to enhance its effects on cellular health, support healthy aging, and optimize cellular function.

A few of our clients reported a significant change in their energy and sleep patterns upon using this product.

People also like the long-term effects that might reduce some natural aging in the body, according to an article in Cell Reports [1].

Amount: 

The important thing to keep in mind with resveratrol is that it’s not suitable for some types of medication.

5 - HPN Nutraceuticals Nicotinamide Riboside (Top Pick for Cognitive Boost)

Rated 4.6/5
4.6
Ingredients
4.5
Price
4.6
User Ratings
4.6
Product Effectiveness
4.5
Dosage
4.6
Purity
HPN Nutraceuticals Nicotinamide Riboside
  • Price per serving : $0.50
  • Key ingredients : Nicotinamide Riboside
  • Form : Capsule
  • Third-party tested : Yes

Pros and Cons

Pros

  • Seems to be working well for improving mood and brain function
  • Claims to enhance your natural metabolism for more effective energy production
  • Positive comments about measurable increases in levels of NAD

Cons

  • The capsules are pretty big and may take getting used to

Who is it for?

Who is it for?

  • • Those needing cognitive function improvement
  • • People looking to enhance mood and brain function

Who is it not for?

  • • Those who struggle with large capsules

Final Verdict

Excellent for cognitive and mood enhancement, ideal for those needing mental boosts. Capsule size may be an issue.

HPN received positive feedback from our reviews, particularly its various forms of nutritional science benefits.

One of my clients reported significant improvement in focus and mental stamina. Other benefits mentioned by our clients include improved physical performance, mental boosts, and an improved immune system.

This NAD booster is designed to improve cellular health by supplying the human body with 311 mg of NAD3 which comprises Wasabia japonica, theacrine,  and cuprous niacin, all of which help improve cellular energy metabolism to support a healthy lifestyle.

It also claims to help reduce metabolic disease issues that could often leave you feeling sluggish.

Amount: 

You might need to get used to the size of the capsules, as they aren’t the easiest to swallow.

6 - Thorne Research ResveraCel (Best for Older Athletes)

Rated 4.6/5
4.7
Ingredients
4.5
Price
4.5
User Ratings
4.6
Product Effectiveness
4.5
Dosage
4.6
Purity
Thorne Research ResveraCel
  • Price per serving : $1.00
  • Key ingredients : Nicotinamide Riboside, Resveratrol
  • Form : Capsule
  • Third-party tested : Yes

Pros and Cons

Pros

  • Seems to work well for stabilizing aging effects at the cell level
  • Batches go through multiple rounds of testing to ensure quality and purity
  • May also support healthy heart and cognitive function
  • Gluten, soy, and dairy-free

Cons

  • The capsules are almost an inch long, making them a bit difficult to swallow

Who is it for?

Who is it for?

  • • People needing stable aging effects
  • • Those seeking high-purity supplements

Who is it not for?

  • • Those who struggle with large capsules

Final Verdict

Effective in stabilizing aging effects and ensuring purity. Suitable for older athletes, but capsules are large.

Thorne's products are considered one of the best NAD supplements on the market today and a top choice for older athletes.

As one of the most trusted brands in providing dietary supplements, Thorne Research's ResveraCel is another product where we saw quite a few positive comments online about how it could improve the levels of NAD precursors.

This would explain why quite a few older people seem to show signs of improvement within weeks. Benefits include cognitive function, DNA repair, cellular energy production, and cell metabolism.

With 415 mg of nicotinamide riboside NR, ResveraCel claims to promote healthy aging by targeting the effects from inside and out. It also has added clinically proven ingredients like quercetin phytosome, trans-resveratrol, and betaine anhydrous to increase NR's effectiveness.

Amount: 

These capsules are possibly the largest we encountered, so keep that in mind before ordering.

7 - Ultra Health NAD+ (Best Anti-Aging)

Rated 4.5/5
4.6
Ingredients
4.4
Price
4.5
User Ratings
4.5
Product Effectiveness
4.5
Dosage
4.5
Purity
Ultra Health NAD+
  • Price per serving : $1.33
  • Key ingredients : Nicotinamide Riboside
  • Form : Capsule
  • Third-party tested : Yes

Pros and Cons

Pros

  • Claims to target cellular level immunity to help with age-related problems
  • Test results show it may be effective at triggering NAD precursors
  • It’s a cheaper option but still seems to work well

Cons

  • Requires taking two capsules per day

Who is it for?

Who is it for?

  • • Budget-conscious individuals
  • • Those seeking anti-aging benefits

Who is it not for?

  • • Those who forget multiple daily doses

Final Verdict

Affordable and effective in boosting NAD levels and mental capacity. Requires consistent dosing.

Ultra Health NAD+ is among the cheaper NR supplement options available. However, that doesn’t mean it uses inferior ingredients that aren't backed by science.

We saw some blood test results from users that showed an increase in NAD levels after a month of consistent intake.

Clients say they experienced a significant increase in cellular energy production and mental capacity with this supplement. Some also noticed fewer wrinkles on their skin.

Amount: 

With 500 mg of NR, it's a 100% vegan-friendly supplement made with microcrystalline and vegetable cellulose.

However, you will need to take two capsules for the full dosage. It could be a problem if you have a tendency to forget taking booster supplements more than once every day.

8 - Genex Formulas Nicotinamide Riboside

Rated 4.5/5
4.5
Ingredients
4.4
Price
4.5
User Ratings
4.5
Product Effectiveness
4.4
Dosage
4.5
Purity
Genex Formulas Nicotinamide Riboside
  • Price per serving : $1.20
  • Key ingredients : Nicotinamide Riboside
  • Form : Capsule
  • Third-party tested : Yes

Pros and Cons

Pros

  • Keeps the formula simple, so you know what you get
  • Positive comments about boosted energy levels and mood
  • Doesn’t contain allergens and fillers that might cause side effects

Cons

  • Some reports about missing pills in bottles

Who is it for?

Who is it for?

  • • Those needing energy boost
  • • Individuals wanting simple formulations

Who is it not for?

  • • People concerned about potential missing pills

Final Verdict

Simple and effective for boosting energy and mood. Suitable for those who prefer minimal ingredients.

Close to the last of our best recommended NAD boosters is from another company that has kept the formula as simple as possible with only 300 mg of nicotinamide riboside as its main ingredient.

It should support higher NAD levels within about four weeks, which is a bit longer than other products but still a decent time frame for an overall increase.

Customers say this supplement gave them more energy to perform everyday tasks, even with a high fat diet. It also made their hair and nails grow faster and reduced the appearance of sunspots on their skin. Their sleep and focus also improved as well.

Amount: 

We did notice that a few people have complained about the bottles not containing the right number of pills.

9 - Vivalifer NMN Super Nicotinamide Mononucleotide

Rated 4.4/5
4.5
Ingredients
4.4
Price
4.5
User Ratings
4.4
Product Effectiveness
4.4
Dosage
4.4
Purity
Vivalifer NMN Super Nicotinamide Mononucleotide
  • Nicotinamide Mononucleotide (NMN) : 500 mg

Pros and Cons

Pros

  • Positive comments about boosted NAD+ levels providing more energy
  • Free from common allergens and artificial additives
  • Seems to support better sleep cycles

Cons

  • The capsules are not the smallest to swallow

Who is it for?

Who is it for?

  • • People needing better sleep
  • • Those looking for natural energy boost

Who is it not for?

  • • Those who struggle with large capsules

Final Verdict

Effective for improving sleep and energy. Capsules are a bit large, so consider that.

Vivalifer NMN is probably one of the best NMN products on the market.

A study mentioned in an article from Sleep Doctor shows that the mononucleotide type used in this product might help with getting better sleep [2]. That might have significant rejuvenating benefits within just a few days.

We also saw quite a few comments where people said they had their NAD levels tested and that there was a measured improvement after taking it for several weeks.

Amount: 

The only thing we found is that the capsules are a bit on the large side.

"There’s a complex, two-way relationship between NAD and circadian rhythms, one that influences sleep-wake patterns and other important physiological processes, including metabolism."

- Dr. Michael Breus, Sleep Specialist

10 - Toniiq NMN

Rated 4.4/5
4.4
Ingredients
4.3
Price
4.4
User Ratings
4.4
Product Effectiveness
4.3
Dosage
4.4
Purity
Toniiq NMN
  • NMN : 500 mg

Pros and Cons

Pros

  • UltraNMN formula claims to be of the highest grade
  • Claims to be shelf-stable, so doesn’t require refrigeration
  • It’s an affordable bulk order option

Cons

  • Requires two capsules daily for the full dose

Who is it for?

Who is it for?

  • • Older individuals needing cognitive boost
  • • Those seeking high-purity NMN

Who is it not for?

  • • Those who dislike taking multiple pills

Final Verdict

High purity and effective for cognitive function. Requires two daily pills, which may not be convenient for everyone.

This NMN (nicotinamide mononucleotide) supplement from Toniiq claims to be one of the stronger options available, which could be a good choice for older people trying to achieve a more significant boost for cognitive function.

Aside from having minimalist packaging, it also boasts a highly purified form of NMN of at least 99% purity which enhances its potency in releasing precursors to your body to produce more NAD.

The product has also been designed to be stable at room temperature, which means you won’t need to keep it in the fridge.

Clients who used Toniiq NMN reported experiencing sustained energy boosts and a sharper mind upon taking it. It's a great product if you're still doing high intensity interval training for muscle growth. The supplement also improved the texture of their skin, giving it a softer and healthier appearance.

Amount: 

Just keep in mind that the larger dose will require taking two pills per day, which might not suit people who don’t like swallowing capsule supplements.

11 - MAAC10 NMN

Rated 4.3/5
4.3
Ingredients
4.3
Price
4.3
User Ratings
4.3
Product Effectiveness
4.2
Dosage
4.3
Purity
MAAC10 NMN
  • NMN : 125 mg

Pros and Cons

Pros

  • Claims to be more stable and effective than nicotinamide riboside
  • Tested for 99% purity and higher-grade content
  • Comes with a 60-day money-back guarantee for peace of mind

Cons

  • The dosage is quite low, so may not be as effective as the others

Who is it for?

Who is it for?

  • • Those starting with NMN supplements
  • • People looking for stability and effectiveness

Who is it not for?

  • • Those needing higher dosages

Final Verdict

Stable and effective, good for beginners. Dosage might be low for significant changes.

We like that MAAC10 takes consistency and quality seriously. Every batch of this supplement is tested to ensure you always get the right grade and concentration for cellular repair.

The amount of nicotinamide mononucleotide per serving is quite low at 125 mg so you may need to take more than one serving per day, depending on your needs. It's best to consult a licensed healthcare provider first if you plan to take more than the approved dosage.

You also have the option to ask for your money back within 60 days of purchase if you’re not satisfied with the changes it might bring to your life.

Many customers say that MAAC10 NMN supplements improved their physical performance, increased their cellular energy, and gave them better mental clarity within a few weeks of taking it. The product also had mood-boosting effects.

Amount: 

I would say that this isn’t the best option if you’re looking to make a more significant change in your body as the dosage is quite low. Regardless, this healthier aging supplement is a good place to start before fully committing to the lifestyle.

12 - NMN Plus

Rated 4.2/5
4.2
Ingredients
4.2
Price
4.2
User Ratings
4.2
Product Effectiveness
4.2
Dosage
4.2
Purity
NMN Plus
  • NMN : 300 mg

Pros and Cons

Pros

  • Uses a simple formula with no additives or fillers
  • Could improve your mood and sleep pattern
  • Seems to have positive reviews about the boosted brain function

Cons

  • Some of the advertised benefits might take more than 30 days to kick in

Who is it for?

Who is it for?

  • • People seeking simple formulas
  • • Those looking to improve mood and sleep

Who is it not for?

  • • Those expecting quick benefits

Final Verdict

Simple and effective for mood and cognitive health. Benefits may take a month to appear.

This NMN supplement stood out because the company made it clear that they kept the formula as simple as possible to avoid any use of allergens or fillers. It literally contains 500 mg of nicotinamide mononucleotide only, nothing unnecessary for a healthy diet.

Users have reported that they feel a better mental attitude and improved brain health upon taking this supplement [3].

We also noted that people are saying their sleep patterns have improved. The improved resting habits enhance cognitive health and other bodily functions, resulting in better overall health.

Amount: 

While most supplements typically need to be stored in low temperatures, this supplement from NMN Plus is completely stable in non-refrigerated temperatures which makes it convenient to use.

We just found that some potential health benefits didn’t show up until consistently using it for about a month.

How We Tested The Best NAD+ Supplements

Navigating the complex world of NAD supplements can be daunting, but with the right criteria in hand, one can make informed decisions. Through extensive research and personal trials, we sifted through numerous products to bring you the best in the category.

1. Bioavailability and Effectiveness

At the core of any supplement is its ability to be absorbed and utilized by the body. We assessed the bioavailability of various NAD supplements, ensuring that they effectively raise the body's NAD levels.

The best supplements on our list have formulations that optimize uptake, providing tangible benefits such as enhanced energy, improved cognitive function, and overall cellular health.

2. Ingredient Purity and Sourcing

With the increasing demand for NAD supplements, it’s vital to discern between high-quality products and those that might cut corners. We prioritized supplements that source their ingredients ethically, ensuring purity and potency. Moreover, products that openly disclose their ingredient sources and are free from unnecessary fillers and additives scored higher in our assessment.

3. Scientific Backing

Given the burgeoning research surrounding NAD and its potential benefits, we delved into clinical studies, peer-reviewed articles, and the latest research to ensure the products on our list are not just effective but also safe. Supplements that could demonstrate evidence-based benefits and had a robust scientific foundation were given precedence.

4. Consumer Experience and Transparency

In the supplement world, trust is paramount. We valued companies that were transparent about their production processes, third-party testing, and customer reviews. A positive consumer experience—from ease of use, dosage, and recommendations to customer service—played a significant role in our selection.

After all, the best products are not just about efficacy but also about building a trustworthy relationship with users.

Buyer's Guide for the Best NAD+ Supplements

When considering the purchase of NAD+ supplements, I've found it's crucial to evaluate several factors to ensure you are selecting a product that aligns with your specific needs and provides the desired benefits.

Over the years, I've explored various NAD+ supplements and have learned the importance of the following key factors:

  1. Form of NAD+ supplement: NAD+ supplements come in various forms, such as nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and straight NAD+. Research the differences and effectiveness of each form.
  2. Bioavailability: Check how well the supplement can be absorbed and utilized by the body. Some forms of NAD+ are more bioavailable than others.
  3. Dosage and concentration: Look at the dosage and concentration of the active ingredient. Ensure it aligns with the recommended or researched effective dosages.
  4. Purity and quality: Choose supplements that are high in purity and free from unnecessary fillers, additives, or artificial ingredients. The quality of the raw materials used is crucial.
  5. Third-party testing and verification: Reputable brands often have their products tested by independent labs to ensure potency, purity, and safety.
  6. Manufacturing standards: Check if the supplement is manufactured in facilities that adhere to Good Manufacturing Practices (GMP) and whether they comply with FDA regulations or equivalent standards in your country.
  7. Synergistic ingredients: Some NAD+ supplements include additional ingredients meant to enhance absorption or provide complementary benefits. Understand the role of these ingredients and if they align with your health goals.
  8. Potential side effects and interactions: Be aware of any potential side effects or interactions with other supplements or medications you may be taking.
  9. Scientific research and evidence: Look for supplements backed by scientific research and clinical trials to ensure their efficacy and safety.
  10. Your specific health goals: Consider your health objectives, such as anti-aging, improved energy levels, or cognitive function, and choose a supplement that aligns with these goals.

What is Nicotinamide Adenine Dinucleotide (NAD+)?

NAD

Nicotinamide adenine dinucleotide or NAD+ is a coenzyme found in all living cells that plays an important role in cellular health, particularly energy metabolism and gene expression. NAD+ helps cells create more energy so we can have more cells to work for the body, hence better cell function.

Aside from aiding in healthy aging, NAD+ fuels several biological processes [4].

These include:

  • Increasing damaged DNA repair
  • Converting food into energy
  • Supporting cells' defense systems
  • Setting circadian rhythms or internal body clock

However, as we age, our healthy supply of NAD+ declines, and so does our longevity. It becomes pretty easy for our body to develop chronic diseases like heart disease, vision loss, diabetes, and Alzheimer’s disease.

But that's not the only catch. Even other metabolic stressors and neuronal stress can also cause a decline in NAD+ levels and these include lack of physical activity, sleep disturbance, and too much alcohol intake.

As such, NAD+ booster supplements like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) supplements have quickly become an easy and efficient way to effectively increase NAD+ levels.

What's The Difference Between NR and NMN?

Here are the main differences between NR and NMN:

  • NR and NMN have roughly similar structures, but NMN has an extra phosphate group which makes it a larger molecule than NR. With this, scientists suggest that NMN is too large to enter cells, so it must be first converted to NR.
  • NMN is an immediate precursor of NAD+, which means that it directly converts to NAD+ with the help of an enzyme. NR, on the other hand, needs to be converted into NMN first.

While both nicotinamide riboside and nicotinamide mononucleotide are precursors to the essential molecule NAD+, there are small differences between the two that may affect the efficacy and efficiency of conversion to NAD+.

It should also be noted that the body cannot make NAD+ without the amino acid tryptophan. Thus, it's important to take supplements with tryptophan to reap the potential health benefits of NAD+ booster supplements.

So which is better, NR or NMN? Unfortunately, there is not enough information to answer that question right now, but the good news is that both precursors have been proven to be safe for human use [5]. More research and clinical trials are needed to verify their effects and efficacy.

Benefits of NAD+ Supplements

A man showing his both arm muscles
  • Promotes healthy aging process. While NAD+ supplements won't reverse time to make you younger, studies show that they can help to counter age-related health conditions like diabetes, vision loss, heart disease, cancer, and arthritis [6].
  • Helps in protecting brain cells. Since NAD+ helps protect cells from impaired mitochondrial function and oxidative stress, scientists believe that these are linked to the development of age-related brain disorders like Parkinson's and Alzheimer's disease [7].
  • Aids in weight loss. Studies suggest that nicotinamide riboside can help speed up the metabolism of mice by increasing thermogenesis, which can result in better weight management [8].
  • Enhances muscle function. While most people use NAD+ supplements for health reasons, some athletes and exercise enthusiasts also take one to improve their physical performance. Studies have linked NAD+ supplements to boost muscle strength, function, and endurance [9].

Side Effects of NAD+ Supplements

NAD+ boosters, both NR and NMN, are generally safe for human use, as several clinical human trials show. A study shows that taking 1,000 to 2,000 mg of nicotinamide riboside per day does not cause adverse side effects [10].

However, other studies reveal that some users may experience mild side effects such as fatigue, nausea, diarrhea, headaches, and indigestion. To prevent these side effects, stick with the recommended dosage of your NAD+ supplement.

From my extensive experience with multiple supplements, I always emphasize reading the label and adhering to the recommended dosage to avoid such side effects.

You must also be discerning when you buy these products since you might be getting fake or expired ones. But before all that, always consult a qualified healthcare provider before making purchases or changing your supplement regimen.

NAD+ supplements are usually in the form of capsule or tablet, like the products mentioned in this review. Most brands recommend taking 200–500 mg of either nicotinamide riboside or nicotinamide mononucleotide per day which is the equivalent of 1 to 2 capsules.

While supplements are a direct way to boost NAD+ levels, it's worth noting that a balanced diet plays a pivotal role too.

Foods like milk, yeast, and green vegetables are rich in precursors to NAD+, aiding its natural production in the body. Incorporating such foods into your daily diet can complement the effects of NAD+ supplements, offering a holistic approach to maintaining optimal levels.

It's best to consult a doctor first before taking more than the recommended daily dosage of NAD boosters.

FAQs

Is NMN Better Than NAD?

No, NMN isn’t better than NAD, as they are entirely different substances. NMN works as a precursor to NAD, meaning it is converted to NAD with the help of specific enzymes. Studies have shown that taking NMN supplements effectively increases NAD levels in your body and supports healthy aging process. With this, you can expect a considerable life extension.

At What Age Does NAD Decrease?

NAD levels decrease from a young age after puberty. But the most notable reduction comes after age 50 when measured levels might drop as much as 50%. This is why it’s a commonly recommended supplement for older people to support healthy aging process.

What Is the Best Source of NAD?

The best source of NAD includes fish such as tuna, salmon, and sardines. Cow’s milk, mushrooms (especially the crimini), green vegetables (including peas and asparagus), yeast, and whole grains are also excellent sources, making them natural NAD boosters.

How Can I Increase My NAD Naturally?

You can increase NAD naturally by exercising regularly, spending time in heat sources like saunas and hot tubs, limiting sun exposure, eating food items considered as NAD boosters, and adopting intermittent fasting and ketosis.

Our Verdict on the Best NAD+ Supplement

All of our testing has made us conclude that Wonderfeel Youngr is the best NAD/NMN supplement you can buy at the moment. It seems to provide the best form for higher absorption, and its success is backed by science.

Our clients have all had positive things to say about it and their performance at the gym and motivation to exercise more have all improved.

You should also try to take advantage of the bulk discounts available, which most other products don’t offer.

And make sure you report back to us how quickly you think it resulted in some improvements for your body.

Our #1 Recommendation

Wonderfeel® Youngr™ (Best Overall)

Wonderfeel® Youngr™

Rated With Total Shape's Scoring System

4.9
Ingredients
4.8
Price
4.7
User Ratings
4.9
Product Effectiveness
4.8
Dosage
4.9
Purity
Pros
  • Supports recovery after long days
  • Aids in aerobic activities
  • Reasonably priced
  • Get the BEST PRICE until the end of June
Cons
  • The 900 mg dose may be too much for certain people
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About The Author

James Cunningham, BSc, CPT
Staff Writer & Senior Coach
James Cunningham, BSc, CPT holds a BSc degree in Sport & Exercise Science from University of Hertfordshire. He's a Health & Performance Coach from London that brings a unique blend of academic knowledge of health supplements and practical exercise experience to the table for his readers.
Learn more about our editorial policy
Dr. Kristy June Dayanan, BS, MD is an author with a BS degree from University of the Philippines and an MD from University of Perpetual Help System. Her ability to simplify medical science complexities and dietary supplement jargon for the average reader makes her a valued medical fact checker and reviewer.
Learn more about our editorial policy
Dr. Harshi Dhingra, MBBS, MD is a published peer-reviewed author and renowned physician from India with over a decade of experience. With her MBBS from Bharati Vidyapeeth and an MD from Rajiv Gandhi University, she actively ensures the accuracy of online dietary supplement and medical information by reviewing and fact-checking health publications.
Learn more about our editorial policy

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2 thoughts on “Best NAD+ Supplement
Deal With Natural Aging and Increase Energy

  1. I’m actually curious about is how much you should take to avoid making this supplement a replacement for natural NAD+ production or the use of natural stored NAD+, and if there’s a bigger chance of this happening if you start taking it at a young age.

  2. Great delivery. Great arguments. Keep up the amazing spirit.

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Our ingredients score is based on 3 factors including: transparency, blend disclosure, and dosage accuracy. We conduct third-party lab verification of ingredients. The score is an objective measure of the lab test results compared to the product label. For more information see our ingredients score explanation here.
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