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ONNIT Alpha Brain Review:
Side Effects, Ingredients & More

Tyler Sellers
Published by Tyler Sellers
Fact checked by Donald Christman, BHSc FACT CHECKED
Last updated: November 6, 2021

I started getting into nootropics over a year ago and have been experimenting with different supplements.

So far, that has often meant combining a few different products based on recommendations from my nutritionist, but she recently recommended taking Alpha Brain by ONNIT.

Usually, I’m not convinced when supplements contain a long list of ingredients (more on these below), but I had to give it a try based on that recommendation.

Our team ran a trial for a few months, and we have some interesting findings to report.

What Is ONNIT Alpha Brain?

Onnit Alpha Brain

ONNIT Alpha Brain is one of the most recent products in the nootropic supplement market.

It claims to combine natural ingredients to boost your cognitive function and mental processing speed.

What this means is that you may be able to focus on tasks more easily without getting distracted, and problem-solving may seem like it happens with ease.

What we like about it is that ONNIT has made this a caffeine-free nootropic, which is an important factor.

See, many other nootropics include stimulants, which might fool you into thinking that you got some boosted brain activity.


Joe Rogan is an outspoken fan of Alpha Brain, and in a few interviews has mentioned that it seems to help him get in the zone a lot easier, which increases his productivity.

Essentially, it claims to help anyone who needs to use their brain at maximum capacity for better focus and, ultimately, motivation.

Let’s see how it does this.


ONNIT Alpha Brain Ingredients

Supplement Facts of ONNIT Alpha Brain

ONNIT throws a lot of fancy terms like flow state and alpha waves out there, so we had a nutritionist do some analysis.

Here’s what we found.

1. L-Tyrosine

There are many situations in life where you will feel clearly under stress. Many times, this is purely an overreaction in the brain where you feel you’re going in every direction at the same time.

Some research has shown that L-Tyrosine might increase dopamine and adrenaline production, which are hormones that may help you better deal with stress.

Through a calming effect on the brain, it might slow you down enough to focus on solving the problem, and it can actually appear like the solution is very obvious.

2. L-Theanine


Scientists have linked the amino acid L-Theanine to increased production of serotonin and dopamine [1]. These are two important hormones that stimulate certain activity in the brain.

You might have heard of these as the feel-good hormones, as an increase may make you feel more relaxed and chilled out.

But in addition to making you feel relaxed, they might also promote alpha wave activity in your brain. This slower brain wave has been shown to support creative thinking, focus, and problem-solving.

3. Oat Straw Extract

This was a completely new ingredient for me, even though I’ve taken several different nootropics. Apparently, oat straw has the potential to directly fuel brain activity.

“Oat straw extract boasts a dense nutrient profile. It’s packed with things like zinc, manganese, and iron. It’s also shown to have a number of health benefits for your brain and emotional health, while also helping to ward off diseases associated with chronic inflammation.” - Ashley Lall, Writer at

Fortunately, there have been a few studies that have some very interesting results.

One, in particular, found that there were significant cognitive performance effects from taking oat extract supplements [2]. Specifically, they showed improved memory function for word recall and faster thinking times to solve problems effectively.

4. Phosphatidylserine


Don't ask me how to pronounce it; my nutritionist tried to teach me for 5 minutes before we gave up.

What was more interesting is what it might do to your brain.

It’s a type of fat, and apparently, your body predominantly needs it for the membranes in brain cells. Basically, the stuff that holds the brain cells together.

As your brain is constantly building and replacing cells and connections between them, it’s easy to understand that this substance may play a key role in the overall health and function of your brain.

5. Cat’s Claw Extract

Don’t worry; no animals were harmed to create this extract.

It’s a funny name for an Amazonian rainforest plant, and there is some evidence to suggest that it may help with cell reproduction and repair.

But, our research found more benefits to immune health and as an anti-inflammatory [3]. This might still make it a positive ingredient for your brain, but I haven’t been able to find enough evidence that it’s going to make nootropics more powerful.

6. Alpha GPC


Now we get into what ONNIT calls its focus ingredients.

This ingredient has been scientifically linked to the production of acetylcholine, which is a neurotransmitter that directly controls brain and nerve function.

What we found very interesting is a study that looked at a link to learning and memory [4]. While they weren’t able to establish that link, they did find results supporting its ability to help with attention span.

The longer you might be able to concentrate on a difficult task, the more likely you’ll come to a solution.

7. Bacopa Monnieri

Here’s another one of the more fascinating ingredients.

Some scientists had believed that it could influence memory function by making it easier to learn new topics or tasks.

But, it turns out it could be more supportive of keeping your attention and focus where it needs to be.

Apparently, it works by playing a role in the growth of the parts of nerve cells that receive messages, which should help to speed up the flow of signals.

8. Toothed Clubmoss Extract

Toothed Clubmoss Extract

Scientists have long been studying this moss, and the medical industry has found some links that it might help treat people with degenerative brain diseases or other damage.

One study, in particular, managed to show that it has an interesting impact on acetylcholine [5].

It’s not that it promotes producing more of it, but rather that it slows the breakdown to help maintain higher levels.

9. L-Leucine

You might be familiar with this amino acid as it’s one of the BCAAs that many athletes rely on for better muscle function and recovery.

My high school coach and biology teacher always said that the brain is like a muscle in more than one sense. Muscles need to be trained, but you also need to feed them and your brain similar nutrients to help it repair and become more effective.

“Some evidence suggests that branched-chain amino acids may also improve cognition in people with declining brain function due to liver disease.” - Ana Aleksic, MSc (Pharmacy).

L-Leucine may do just that by promoting more effective protein synthesis in the brain.

10. Pterostilbene

Here’s another ingredient that I can’t pronounce, but I did find a study that supported the use of it in nootropics [5].

The study showed a link to maintaining brain cell structures and protecting nerve cells from damage.

Some other studies are still ongoing to determine what effect it might have on memory and other cognitive functions, but I wouldn’t discount it yet.

Other ONNIT products: ONNIT New Mood Review

Suitable For Men & Women

Onnit Alpha Brain

ONNIT Alpha Brain

We earn a commission if you click this link and make a purchase at no additional cost to you.

How Does It Work?

taking pills during breakfast

Let’s start with the basics.

You take Alpha Brain on a daily basis as two capsules with a light meal. I would suggest taking it first thing in the morning with breakfast to kickstart your day.

Alternatively, you might want to take it about 30 to 60 minutes before you have a particularly complex problem to solve, e.g., an exam or a project at work.

Once you take the nootropic capsules, your body should be able to absorb the active ingredients in less than an hour.

ONNIT claims that the neurotransmitters then start to kick in and improve your cognitive performance. It should feel like you can think more clearly.

One thing I would point out is that it might take a few weeks to build up in your system to trigger these boosts more effectively.

So, if the first dose doesn’t seem to do much, then keep with it for a couple of weeks.

Pros and Cons

Onnit Alpha Brain

So, our team took these for a month, and we had a few clients who were willing to help out as well.

Overall, we gathered more benefits than we expected, most notably that the product did seem to improve memory, focus, concentration, and attention span.

We had a few students who felt they managed to study for longer than before.

And our nutritionist confirmed the ingredients were overall classed as safe with enough scientific backing to make them suitable as nootropics.

  • All-natural ingredients seem to be supported by scientific evidence
  • Positive reviews from people about improved focus and memory
  • Dairy, soy, and gluten-free to avoid most common food allergies
  • Some bulk order discounts would be great

Suitable For Men & Women

Onnit Alpha Brain

ONNIT Alpha Brain

We earn a commission if you click this link and make a purchase at no additional cost to you.

The only thing I wish ONNIT would do is come up with some bulk order promotions to make long time use more affordable.

Where Should You Buy It?

I don’t know how many times I’ve said this, but there are only two places I would ever consider going for supplements.

First of all, buying directly from ONNIT’s online store is possibly the safest option. There are too many reports of fake supplements that, at best, will do nothing for you. At worst, they might be harmful to your health.

The other option is to buy from reputable online retailers, but I have found that it’s not always available in most of these stores.

Basically, don’t take any risks with anything that you’ll put inside your body.

Side Effects


Alpha Brain seems to have little to no side effects based on our experience and all the online reviews we read.

We did notice a few people mentioned that they got some upset stomach, but this could be more related to a sensitive stomach and possibly taking more than the recommended dosage.

Fortunately, this product doesn’t contain any stimulating ingredients (e.g., caffeine), so even when you take Alpha Brain later in the day, it shouldn’t make you jittery or sleepless.

Customer Reviews

ONNIT Alpha Brain Feedback

Here are a couple of online reviews that we thought were similar to our experience.

This Berkeley student has been taking Alpha Brain for 2 months and has found that it allows him to focus on complex tasks a lot more easily. He plans to take it consistently, especially during exam prep times.

- Philip from Mountain View

Michiko noticed that this nootropic seemed to lift the mid-afternoon brain fog without needing to get a sugary treat. She also thought that her memory had improved throughout the day. - Michiko from Seattle

Danny is an architect, and he noticed the benefits of better attention to detail and the ability to spend more time on certain design tasks. - Danny from NY


Does Joe Rogan Take Alpha Brain?

Yes, Joe Rogan takes Alpha Brain and has promoted it on his podcast. He has specifically said that it seems to help him find the right words and formulate better sentences for interviews.

Can You Take Alpha Brain Every Day?

Yes, you can take Alpha Brain every day. You might want to start with a lower dose to see how it works, but taking 2 capsules a day shouldn’t have any negative effects.

Should You Give ONNIT Alpha Brain A Try?

Yes, we believe this is one of the more advanced nootropics available, and it has helped our team accomplish tasks a lot more easily.

We love the mental clarity, and some of us take it to replace an afternoon coffee.

Order yours today and then report back to us how it worked out for you.


Onnit Alpha Brain

Onnit Alpha Brain
Ingredient quality
Overall Score 5.0
  • All-natural ingredients seem to be supported by scientific evidence
  • Positive reviews from people about improved focus and memory
  • Dairy, soy, and gluten-free to avoid most common food allergies
  • Some bulk order discounts would be great

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