10 Best Supplement Stacks for Weight Loss (2024 Updated)

Benedict Ang, CPT, PN1-NC
Published by Benedict Ang, CPT, PN1-NC | Staff Writer & Senior Coach
Last updated: March 30, 2024
FACT CHECKED by Dr. Kristy Dayanan, BS, MD
We personally test every product featured in our reviews and guides. By ordering products anonymously and getting a group of independent testers, we are able to get first-hand experience and provide data-driven recommendations. Learn more.

As a certified fitness coach, I’ve noticed that most of my clients reach out for fat-burning stacks when their goal is to lose pounds fast.

With the help of my dietician, I dedicated my time to researching the best stack to burn fat based on its ability to suppress appetite, provide energy, and stabilize mood.

Do all fat-burning stacks positively impact your weight loss program? Read on and find out.

The Best Weight Loss Stacks

Editor's Choice
Transparent Labs Fat Burning Essentials Stack
Transparent Labs Fat Burning Essentials Stack
Rated 5.0/5
Click For Best Price
2nd Best Choice
CrazyBulk Bulking Stack
CrazyBulk Bulking Stack
Rated 4.9/5
Click For Best Price
3rd Best Choice
PhenQ and Gorilla Mode
PhenQ and Gorilla Mode
Rated 4.8/5
Click For Best Price

Our Top 10 Weight Loss Supplement Stacks (May 2024)

1 - Transparent Labs Fat Burning Essentials Stack (Best Overall & for Men)

Rated 5.0/5
5.0
Effectiveness
5.0
Ingredients
4.9
Price
Transparent Labs Fat Burning Essentials Stack

Pros and Cons

Pros

  • Features science-backed non-proprietary blends
  • Recommended for those who are sensitive to stimulants/caffeine
  • There are no artificial sweeteners or coloring
  • Non-GMO and gluten-free

Cons

  • Not suitable for people sensitive to caffeine

This supplement stack contains caffeine that boosts your energy and increases your focus during a workout.

Typically, the pre-workout stacks help you burn fat 24 hours a day, boost your metabolic activity and immune function, and reduce cravings during the day [1].

What stood out to me the most was the chromium picolinate in the PreSeries LEAN pre-workout that's part of this fat loss stack. It helped me burn fat I couldn't otherwise shed with other ingredients.

With all these supplements, you could also start with the Transparent Lab Fat Burner, which is the biggest difference maker in the stack.

2 - CrazyBulk Bulking Stack (Best for Strength Training)

Rated 4.9/5
5.0
Effectiveness
4.9
Ingredients
4.8
Price
CrazyBulk Bulking Stack

Pros and Cons

Pros

  • Maintains muscular strength during long exercises
  • Beneficially impacts protein synthesis in muscles for faster recovery
  • Contains a low amount of sugar and caffeine

Cons

  • Requires a reminder to take it at different times of the day

CrazyBulk carries a great assortment of top-rated oral steroid substitutes that function well throughout the cutting period.

They include clenbuterol, which effectively supplies oxygen to your muscle systems, dramatically improving your aerobic performance [2].

After testing the CrazyBulk stack for weeks, my male friends said they felt an increase in stamina that enabled them to work out regularly and lose fat.

3 - PhenQ and Gorilla Mode (Best Metabolism Booster)

Rated 4.8/5
4.9
Effectiveness
4.8
Ingredients
4.8
Price
PhenQ and Gorilla Mode

Pros and Cons

Pros

  • The components are all-natural
  • Boosts metabolism
  • Provides a massive boost in nitric oxide (NO) levels

Cons

  • Not recommended for caffeine-sensitive people

Another awesome stack I tried was a combo of PhenQ and Gorilla Mode.

This fat burner suppresses hunger, food cravings, and binging and boosts metabolism, making you lose weight.

You require two scoops of Gorilla Mode pre-workout and two pills of PhenQ each day. You should never exceed the daily dosage.

The stack contains chromium, an essential fat-burner, and improves the body's metabolism of carbohydrates and protein [3].

The combination of Gorilla Mode and PhenQ was something I was skeptical about at first. But, three weeks and 9 lbs lighter, I became a believer. The increased stamina wasn’t just in numbers but something I could feel with every workout, pushing me to limits I hadn’t reached before.

"With enough chromium, muscle cells can enhance muscle building, less extra sugar is stored as fat, and excess fat can be burned as fuel."

- Harry Preuss, M.D.

For PhenQ:

For Gorilla Mode:

4 - Aphro D and PhenQ

Rated 4.7/5
4.8
Effectiveness
4.7
Ingredients
4.7
Price
Aphro D and PhenQ

Pros and Cons

Pros

  • No harmful derivatives or adverse effects
  • Blocks the new fat production
  • Doctor-formulated and FDA-approved

Cons

  • Takes a bit longer to see the results

This pre-workout stack approaches fat loss from five perspectives: fat burning, fat buildup, suppressed food cravings, endurance, and mood.

This approach enables the fat-burning supplement stack to provide multiple advantages for your objectives to lose weight and overall well-being.

However, be aware that it may take approximately a month of constant use to reap the full benefits, so be patient.

Some of my clients claimed to feel less hungry, which helped them eat less and lose around 4–6 pounds after a month and a half.

For Aphro D:

For PhenQ:

5 - Aphro D and Instant Knockout

Rated 4.6/5
4.6
Effectiveness
4.6
Ingredients
4.6
Price
Aphro D and Instant Knockout

Pros and Cons

Pros

  • Eliminates oxidative stress
  • Contains natural ingredients
  • No side effects

Cons

  • Relatively expensive

This stack contains high-quality components like green tea, Schisandra berry, and vitamin D3 that suppress hunger, enhance testosterone levels, boost metabolism, and improve insulin sensitivity.

These benefits improve the way carbohydrates are processed and stored in your body.

Green tea is a fat-burning ingredient due to the presence of catechins known to be bioactive polyphenols. Catechins provide caffeine-like advantages, giving the stimulation necessary to finish your exercises, thus increasing fat oxidation by 16% [4].

As someone always on the lookout for that extra edge in my workouts, Aphro D and Instant Knockout proved to be the allies I didn’t know I needed. The boost in focus and strength wasn’t just noticeable; it was transformative, turning every lifting session into a personal best.

For Aphro D:

For Instant Knockout:

6 - Lean XT and Stim-Free Transparent Labs (Cheapest Option)

Rated 4.4/5
4.4
Effectiveness
4.4
Ingredients
4.5
Price
Lean XT and Stim-Free Transparent Labs

Pros and Cons

Pros

  • Replenishes the body’s lost electrolytes
  • Non-stimulant, and vegan-friendly fat burner
  • Increases lean muscle growth with sustained resistance workout

Cons

  • The stack may cause bloating

This is an all-natural thermogenic fat-burning supplement stack for men. It has no caffeine or any other stimulant.

The products' potent mix was developed using the most efficient science-backed components, such as forskolin, n-acetyl l-tyrosine, and citrulline malate.

Combining these substances helps burn fat and maintain lean muscle mass.

As someone sensitive to caffeine, finding the right supplement was a challenge. Then came along Lean XT and Stim-Free Transparent Labs.

It wasn’t just the weight loss, though that was significant, but the freedom from the constant hunger and cravings - that was the real win.

For Lean XT:

For Stim-Free Transparent Labs:

7 - Instant Knockout and Gorilla Mode

Rated 4.3/5
4.4
Effectiveness
4.4
Ingredients
4.2
Price
Instant Knockout and Gorilla Mode

Pros and Cons

Pros

  • Detoxifies the body of free radicals
  • No remarkable adverse effects
  • Suppresses hunger

Cons

  • The capsules are quite large

This stack includes cayenne pepper seeds containing capsaicin, a substance known for its beneficial impacts on metabolism, appetite suppression, and weight control.

It also boosts insulin sensitivity, resulting in greater energy and a reduced body fat percentage [5].

Other great ingredients include green tea extract for fat burning, glucomannan which makes you feel fuller, and caffeine anhydrous that stimulates your nervous system.

When it comes to the flavor and texture, I found the Gorilla Mode in this stack to be a little gritty, so it might take some time to get used to it.

For Instant Knockout:

For Gorilla Mode:

8 - PhenQ and Testoprime

Rated 4.3/5
4.2
Effectiveness
4.4
Ingredients
4.2
Price
PhenQ and Testoprime

Pros and Cons

Pros

  • Reduces brain fog
  • It is gluten, dairy, and soy free
  • Does not require a prescription

Cons

  • Not suitable for pregnant women and people under 18

Caffeine in this fat burner supplement stack suppresses your appetite and decreases hunger cravings, allowing you to stick to a healthy diet [6].

You may experience a boost in energy and endurance, reduced brain fuzz, increased muscular mass, and an enhancement in sexual prowess.

PhenQ and Testoprime became a part of my fitness journey, and the difference was clear. Every workout was sharper, every lift stronger, and the mirror confirmed what I felt - the fat was disappearing, thanks to the controlled hunger and increased energy.

9 - Capsiplex and PhenQ (Best for Women)

Rated 4.5/5
4.4
Effectiveness
4.5
Ingredients
4.5
Price
A woman holding both Capsiplex and PhenQ supplements

Pros and Cons

Pros

  • Natural healthy sources of caffeine
  • Boosts lean muscle growth
  • Easy to order

Cons

  • Not recommended for pregnant women

Understanding the body's fat-burning processes is key, which is why Capsiplex and PhenQ are top choices for women. Capsiplex, known for its natural ingredients like capsicum, aids in boosting metabolism and burning fat.

PhenQ, with its unique blend including α-Lacys Reset®, targets multiple weight loss areas like fat burning, appetite suppression, and energy increase.

Both supplements effectively help in feeling full and reducing calorie intake. In my practice, women have reported significant weight loss, typically between 4–7 lbs in a month, using these supplements due to their appetite-controlling and metabolism-boosting properties.

For Capsiplex Trim:

10 - Capsiplex and Stim-Free Transparent Labs Pre-workout (Best for Muscle Fatigue)

Rated 4.2/5
4.2
Effectiveness
4.2
Ingredients
4.2
Price
Capsiplex and Stim-Free Transparent Labs Pre-workout on a kitchen table

Pros and Cons

Pros

  • Reduces premature muscle fatigue
  • Maintains a stable blood sugar level
  • Doesn't contain stimulants

Cons

  • It may take about three months for some people to see results

This pre-workout stack, combining Capsiplex and Stim-Free Transparent Labs, is designed for muscle growth, enhanced strength, and improved mental and physical performance. Capsiplex, with its natural ingredients like capsicum, aids in fat metabolism and boosts energy, facilitating more intense workouts.

Upon integrating this combination into my regime, the increase in strength and energy was significant. While weight loss wasn't as quick as with other stacks, the gains in strength and endurance were notably impressive.

How We Tested the Best Weight Loss Stacks

Our journey to identify the best weight loss stacks began with an extensive market analysis.

We established a stringent set of criteria to ensure that our selected products met the highest standards of quality, safety, and effectiveness. These criteria included:

  • Ingredient Quality: We looked for supplements with natural, potent, and scientifically-backed ingredients known for aiding weight loss.
  • Brand Reputation: Companies with a history of delivering quality and satisfaction were our primary focus.
  • Customer Feedback: Real user experiences played a crucial role in our assessment, offering insights into the product’s effectiveness and any potential side effects.
  • Scientific Research: We prioritized products supported by clinical studies and research, ensuring their claims were validated by science.

Buyer's Guide: How We Chose the Best Supplement Stacks?

Close up shot of a gym trainer holding a clipboard

We decided to come up with a buyer's guide that will help you choose the best fat-burning stack.

We did our routine testing with the help of our clients; therefore, you will not waste your money on products that are not suitable for you.

Here is what we considered when making our list.

Product Synergy

We've given great consideration to how the specific elements of a stack function, not just on their own but as part of the overall nutritional picture.

If you're not careful about every aspect of your nutrition, you might be overlooking some potential benefits.

So, if a manufacturer bundles more than two products together, advertising a full package, but a few of the items do not correspond with the eventual objective, we will not recommend it.

Extensive Trial

A gym trainer taking notes down on a clipboard while someone is working out

Many companies claim that their products are backed by scientific evidence, yet some do not.

We want to make sure that the items you buy, especially the stacks, are backed up by clinical evidence.

It is not guaranteed that each product will function the same for everyone, but it can help with performance if used appropriately.

We triple-checked all of the products on the list and tested them for several months to see the most objective results.

Now, we can confirm that these companies offer facts to back up their claims.

Individual Needs

We want to ensure that the stacks offered here are correctly tailored to meet their promises.

It is not worth your effort to purchase something that will not help you attain your goal over time.

As a result, before investing in an expensive stack, ensure that our recommendations meet your requirements.

Also, keep in mind that a stack is not a magical pill. It requires action and commitment to reach your fitness objectives for it to work.

What to Consider Before Buying Pre-workout Supplement Stacks?

A gym coach writing down on a clipboard

Now that you know how we singled out the best products, here is what you should bear in mind when deciding on the best one for your needs.

Manage Your Expectations

While all of the stacks listed here have scientific backing, you should conduct your own analysis and properly study the nutritional values before making your final choice or purchase.

And keep in mind that not all promises made by a product will be valid for every person.

Our systems digest pre-workout supplements differently, so our responses to specific supplements might vary regardless of the facts.

Manage Your Expenditure

Buying a single product at a time may be fine if you only use one supplement to lose fat.

However, individually purchasing multiple products over the same period might rapidly become expensive. You can probably obtain the same supplements at a lower price when you purchase them in stacks.

In addition, you can save money on shipping because everything will be delivered together. After all, you're buying one overall product for losing weight.

Who Should Take a Weight Reduction Stack?

A woman consulting a doctor

You should take a weight reduction stack if you want to suppress your appetite, boost your energy and focus, and burn fat.

The best supplement stacks encourage your metabolic activities, thus causing your body to burn even more calories while building muscle mass.

Incorporating ingredients like caffeine and zinc will help you benefit from the thermogenic fat burner by boosting your strength and focus when exercising and lifting.

Who Shouldn’t Take a Weight Reduction Stack?

You should not take weight reduction stacks if you have harsh health issues or are sensitive to caffeine.

In addition, skinny and slender individuals should avoid taking these types of pre-workout fat-burning supplement stacks as their fat mass may be lower than recommended.

Other Resources You May Like:

FAQs

What is a Supplement Stack?

A supplement stack is a group of supplements that work together to provide better performance.

Do Weight Loss Stacks Work?

Yes, weight loss stacks work by incorporating ingredients such as caffeine and vitamin D that help you focus and feel energized during your workouts. However, it might be too much for you if you're sensitive to stimulants like caffeine. Consider looking for a stimulant-free supplement for your stack.

What Should I Stack With Whey Protein?

You should stack your whey protein with a pre-workout containing a fat burner, omega fatty acids, and essential amino acids (branched-chain amino acids).

Is It Safe to Stack Pre-workout?

Yes, it is safe to stack pre-workouts. It makes your supplements more effective, and you may get more pronounced results.

Our Verdict on the Best Supplement Stack for Weight Loss

After researching and testing numerous pre-workout stacks, Transparent Lab Fat Burning Essentials Stack stood out to be the most productive one.

This stack ensures you burn calories 24 hours a day, increases your metabolism rate and immunological function, and lowers cravings by suppressing your appetite and increasing the feeling of fullness.

Based on online evaluations, customer comments, and my personal observations, I believe this pre-workout stack has the best ingredients to assist you in reaching your fat-burning goals.

Our #1 Recommendation

Transparent Labs Fat Burning Essentials Stack (Best Overall & for Men)

Transparent Labs Fat Burning Essentials Stack

Rated With Total Shape's Scoring System

5.0
Effectiveness
5.0
Ingredients
4.9
Price
Pros
  • Features science-backed non-proprietary blends
  • Recommended for those who are sensitive to stimulants/caffeine
  • There are no artificial sweeteners or coloring
  • Non-GMO and gluten-free
  • Get the BEST PRICE until the end of May
Cons
  • Not suitable for people sensitive to caffeine
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About The Author

Benedict Ang, CPT, PN1-NC
Staff Writer & Senior Coach
Benedict Ang, CPT, PN1-NC is an ex-National Soccer player turned MMA and Kickboxing champion, with ACE CPT and PN1-NC certifications. His advice is rooted in education and experience, ensuring that readers receive scientific and battle-tested insights. His mission is to empower his clients and readers to realize their potential and become the best versions of themselves.
Learn more about our editorial policy
Dr. Kristy June Dayanan, BS, MD is an author with a BS degree from University of the Philippines and an MD from University of Perpetual Help System. Her ability to simplify medical science complexities and dietary supplement jargon for the average reader makes her a valued medical fact checker and reviewer.
Learn more about our editorial policy
Dr. Harshi Dhingra, MBBS, MD is a published peer-reviewed author and renowned physician from India with over a decade of experience. With her MBBS from Bharati Vidyapeeth and an MD from Rajiv Gandhi University, she actively ensures the accuracy of online dietary supplement and medical information by reviewing and fact-checking health publications.
Learn more about our editorial policy

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One thought on “10 Best Supplement Stacks for Weight Loss (2024 Updated)

  1. Interesting article, but I prefer to prioritize muscle gain over weight loss. It’s important to make sure you’re still getting all the necessary nutrients.

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