10 Best Nootropics For Anxiety & Panic Attacks (2024 Review)

James Cunningham, BSc, CPT
Published by James Cunningham, BSc, CPT | Staff Writer & Senior Coach
Last updated: December 10, 2023
FACT CHECKED by Dr. Kristy Dayanan, BS, MD
We personally test every product featured in our reviews and guides. By ordering products anonymously and getting a group of independent testers, we are able to get first-hand experience and provide data-driven recommendations. Learn more.

One of the most common mental health issues is social anxiety.

And while there certainly are more severe forms of anxiety, it can still be a debilitating problem.

As a health and performance coach, I know that mental and physical health go hand-in-hand, and looking after your brain health is one of the most important decisions to make.

To help readers and clients who suffer from social anxiety, I teamed up with a few clients, my dietitian, and a doctor to research and test the best nootropics for anxiety.

Here’s what client feedback looks like after two months of testing.

The Best Nootropics For Anxiety

Editor's Choice
Mind Lab Pro
Rated 4.8/5
Click For Best Price
2nd Best Choice
Onnit Alpha Brain
Rated 4.7/5
Click For Best Price
3rd Best Choice
Gorilla Mind Smooth
Rated 4.7/5
Click For Best Price

Our Top Nootropics For Anxiety Symptoms (June 2024)

1 - Mind Lab Pro (Best Overall)

Rated 4.8/5
4.9
Ingredients
4.6
Price
5.0
User Ratings
4.7
Product Effectiveness
  • Price per serving : $2.30
  • Key ingredients : Citicoline, Bacopa monnieri, Lion's Mane Mushroom
  • Third-party tested : Yes

Pros and Cons

Pros

  • Client feedback confirms it works well to reduce anxiety and panic attacks
  • Great choice of ingredients that cross the blood-brain barrier
  • Doesn’t contain stimulants that could impact blood pressure
  • Comes in easy-to-swallow capsules with effects lasting the whole day

Cons

  • You can only buy it directly on the company website and not in stores

Who is it for?

Who is it for?

  • Individuals seeking enhanced focus and reduced anxiety.
  • Suitable for daily use without the need for stimulants.

Who is it not for?

  • Those seeking immediate relief through prescription medication.

Final Verdict

Mind Lab Pro is a versatile nootropic that offers a sustainable option for managing anxiety and enhancing cognitive performance without the side effects of stimulants. It is ideal for long-term use.

Our testing data and feedback indicate that Mind Lab Pro can help reduce anxiety symptoms the most.

Several of our testers highlighted that the frequency and intensity of their panic attacks were greatly reduced, and they felt more comfortable in social situations.

The most notable ingredient is an amino acid called Phosphatidylserine, which has been proven to have anti-anxiety effects [1].

“Phosphatidylserine is a phospholipid, a fatty substance produced in the body that helps transmit messages between nerve cells in the brain.”
- Caitilin Kelly, MD at verywellmind.com

Important note: our doctor strongly emphasized that nootropics are no substitute for medication if a person is clinically diagnosed with anxiety.

Quick Facts:

2 - Onnit Alpha Brain (Best for Cognitive Function)

Rated 4.7/5
4.7
Ingredients
4.6
Price
4.8
User Ratings
4.7
Product Effectiveness
  • Price per serving : $2.33
  • Key ingredients : L-Theanine, Alpha GPC, Huperzia Serrata Extract
  • Third-party tested : Yes

Pros and Cons

Pros

  • Good results for generalized anxiety and panic attacks
  • Seems to work well on stress hormones and mood swings as well
  • Available as part of a nootropics stack to promote healthy brain cells

Cons

  • The company hides some of the ingredient dosages behind a proprietary label

Who is it for?

Who is it for?

  • Students and professionals needing cognitive enhancement.
  • People experiencing mild anxiety and mood swings.

Who is it not for?

  • Not recommended for those sensitive to herbal extracts due to proprietary blends.

Final Verdict

Onnit Alpha Brain supports both cognitive functions and anxiety reduction, making it a good choice for individuals in high-pressure cognitive roles.

Onnit is another one of the more effective anti-anxiety nootropics.

And we had lots of feedback from our testing team that it can effectively help with social anxiety disorder and prevent panic attacks, or at least reduce their intensity.

Our testing results also show that Onnit Alpha Brain can help improve cognitive function, which was especially highlighted by a few students that helped us with testing.

According to the study found on the National Center for Biotechnology Information website, this seems to be down to a good dose of L-theanine, which has been shown to help with overall brain performance [2].

Quick Facts:

3 - Gorilla Mind Smooth (Cheapest Option)

Rated 4.7/5
4.6
Ingredients
4.8
Price
4.8
User Ratings
4.7
Product Effectiveness
  • Price per serving : $1.50
  • Key ingredients : Choline, Bacopa monnieri, L-Theanine
  • Third-party tested : Yes

Pros and Cons

Pros

  • It can help relieve anxiety levels for up to eight hours at a time
  • Also works to boost cognitive function for better focus and concentration
  • Stimulant-free option helps you avoid jitters and fueling panic disorders

Cons

  • The full dosage will require taking up to six capsules a day

Who is it for?

Who is it for?

  • Best for those needing extended focus and calm.
  • Suitable for long work hours without stimulants.

Who is it not for?

  • Individuals preferring fewer daily supplements, as it requires multiple doses.

Final Verdict

Gorilla Mind Smooth offers a stimulant-free solution for managing anxiety while boosting cognitive function, ideal for sustained mental effort.

Gorilla Mind is a leading brand in the nootropics space, and this one seems to be particularly effective in helping reduce anxiety symptoms.

Our testing group highlighted that they felt a lot calmer in social situations that usually trigger anxiety.

Several studies have shown that L-Tyrosine can help prevent cognitive decline and boost mental energy, which is an added benefit [3].

The main reason we pushed Gorilla Mind Smooth down the list a bit is that it’s a bit less convenient, as you have to take up to six capsules to get the maximum health benefits.

Quick Facts:

4 - Hunter Focus (Best for Stress)

Rated 4.5/5
4.6
Ingredients
4.4
Price
4.6
User Ratings
4.5
Product Effectiveness
Hunter Focus
  • Price per serving : $3.00
  • Key ingredients : Citicoline, Bacopa monnieri, Lion's Mane Mushroom
  • Third-party tested : Yes

Pros and Cons

Pros

  • Can help with acute stress levels and improve overall mood
  • Good choice for getting your mind to focus on work and study tasks
  • You can easily spread out the dosage to enjoy the benefits for longer parts of the day

Cons

  • The capsules are a bit larger than average and more difficult to swallow

Who is it for?

Who is it for?

  • Ideal for those dealing with acute stress and needing focus.
  • Suitable for intensive study or work tasks.

Who is it not for?

  • Not suited for those who prefer smaller, easier-to-swallow capsules.

Final Verdict

Hunter Focus excels in providing mental clarity and stress reduction, making it suitable for high-pressure environments requiring prolonged focus.

A nootropic called Hunter Focus might not sound like the ideal option to fight anxiety, but our tests indicate that a lot of the ingredients that help with focus by crossing the blood-brain barrier can also help to treat anxiety.

The most notable one is Rhodiola Rosea, which has been shown to reduce the stress response to social situations [4].

Quick Facts:

5 - Gorilla Shroom (Best Natural)

Rated 4.5/5
4.5
Ingredients
4.3
Price
4.6
User Ratings
4.5
Product Effectiveness
  • Price per serving : $1.67
  • Key ingredients : Lion's Mane, Cordyceps, Reishi, Maitake
  • Third-party tested : Yes

Pros and Cons

Pros

  • Our testers found that it helped them deal with complex problems with fewer distractions
  • Carefully chosen formula has anti-stress benefits as well
  • Also contains B vitamins to improve blood flow to the brain

Cons

  • You can’t buy it in stores and have to order from the official website

Who is it for?

Who is it for?

  • Individuals interested in natural ingredient solutions.
  • Those needing support with complex problem-solving.

Who is it not for?

  • Those averse to ordering supplements online, as it’s only available directly.

Final Verdict

Gorilla Shroom uses a natural formula to aid anxiety and cognitive challenges, offering a balanced approach to mental health with minimal side effects.

Gorilla Shroom is the second product from Gorilla Mind, and this one has helped quite a few of our testers deal with anxiety disorder.

They also mentioned that they could maintain motivation and focus on complex tasks, which is a known effect of Lion’s Mane mushroom [5].

Based on our tests, it’s also one of the better natural nootropics to help lift brain fog in the morning and provide overall mental energy throughout the day without feeling overly fatigued.

Quick Facts:

6 - NooCube (Best for Memory)

Rated 4.5/5
4.4
Ingredients
4.5
Price
4.5
User Ratings
4.4
Product Effectiveness
  • Price per serving : $1.08
  • Key ingredients : Alpha GPC, Bacopa monnieri, Huperzia Serrata
  • Third-party tested : Yes

Pros and Cons

Pros

  • Seems to work very well in improving long and short-term memory
  • Can help to reduce cortisol levels and provide anti-stress benefits
  • Comes in small capsules that make adjusting the dose easier

Cons

  • There are a couple of ingredients that don’t have enough reliable scientific evidence

Who is it for?

Who is it for?

  • Best for memory improvement and long-term cognitive health.
  • Those looking to reduce anxiety alongside enhancing memory.

Who is it not for?

  • Those skeptical of less scientifically proven ingredients.

Final Verdict

NooCube provides a dual approach to cognitive enhancement and anxiety reduction, making it suitable for individuals focused on both mental clarity and emotional stability.

NooCube is another one of the nootropics for social anxiety and cognitive function that our testing team had some great results with.

One of the ingredients to note is the amino acid L-Tyrosine, which scientists believe can help the brain better deal with stressful situations [6].

And this is something that many of our testers highlighted as one of their favorite things about this product.

Quick Facts:

7 - Qualia Mind

Rated 4.3/5
4.3
Ingredients
4.2
Price
4.4
User Ratings
4.3
Product Effectiveness
  • Price per serving : $0.93
  • Key ingredients : Bacopa monnieri, Alpha GPC, Huperzia Serrata
  • Third-party tested : Yes

Pros and Cons

Pros

  • Can help you think clearly and rationally even when feeling stressed and anxious
  • Positive feedback on improvements in memory
  • Stimulant-free option boosts the central nervous system to help lift brain fog

Cons

  • You might need to order in bulk as it’s often out of stock online

Who is it for?

Who is it for?

  • Suitable for those needing comprehensive cognitive enhancement.
  • People dealing with stressful situations requiring clear thought.

Who is it not for?

  • Those who cannot manage frequent restocking, as it is often out of stock.

Final Verdict

Qualia Mind is designed to offer broad-spectrum cognitive support and anxiety relief, highly effective for people in dynamic and demanding roles.

Qualia Mind is a nootropic that takes a broad approach to brain functions, and our testing data suggests that it can be very effective for dealing with social anxiety symptoms.

This is partially the result of a good dose of Alpha GPC, which has been tied to the neurotransmitter acetylcholine and improved cognitive functions and the ability to think clearly even in stressful situations [7].

Quick Facts:

8 - Leading Edge Health - BRAINPILL

Rated 4.5/5
4.4
Effectiveness
4.5
Ingredients
4.6
Price
  • Vitamin B6 : 5 mg
  • Vitamin B12 : 50 mcg
  • L-Tyrosine : 175 mg
  • Ginkgo Biloba : 100 mg

Pros and Cons

Pros

  • Provides a good boost for problem-solving and memory
  • Works well for reducing stress and anxiety levels
  • Seems to allow you to stay focused on a task for longer

Cons

  • The capsules are quite large and a bit more difficult to swallow

The next one of our recommended nootropics for social anxiety and cognitive function is called Brainpill, and its main aim is to provide mental clarity and improved memory function.

But at the same time, our tests indicate that it can also reduce panic attacks and anxiety.

With a good dose of B vitamins, it seems to work well to improve overall brain health and function as well [8].

Quick Facts:

9 - BiOptimizers - Magnesium Breakthrough

Rated 4.2/5
4.1
Ingredients
4.2
Price
4.2
User Ratings
4.1
Product Effectiveness
  • Price per serving : $1.32
  • Key ingredients : 7 forms of Magnesium (including Glycinate, Malate, Citrate)
  • Third-party tested : Not specified

Pros and Cons

Pros

  • Provides a wide range of different magnesium sources for better bioavailability
  • It can significantly reduce stress and even help with panic disorder
  • Improves sleep patterns to help you start the day more relaxed and refreshed

Cons

  • You probably need to combine it with other alternative medicine to get the best effects

Who is it for?

Who is it for?

  • Athletes and physically active individuals needing mental relaxation.
  • Suitable for those seeking to improve sleep quality alongside stress management.

Who is it not for?

  • Those looking for a more targeted anxiety control without additional dietary changes.

Final Verdict

BiOptimizers provides a unique approach by using different magnesium types to improve bioavailability, greatly benefiting those needing physical and mental relaxation.

This magnesium supplement is often favored by athletes to help them physically and mentally relax after a tough workout day.

However, one of the studies found on the National Center for Biotechnology Information website has shown that magnesium can further impact brain function to help with mild social anxiety disorders [9].

Our tests indicate that you will also sleep a lot better when you take this before bedtime and then wake up more refreshed.

The downside is that you’d need to combine it with other nootropics to get maximum benefits, and this one can work very well with Mind Lab Pro above.

Quick Facts:

10 - NeuroFuel

Rated 4.1/5
4.0
Ingredients
4.1
Price
4.1
User Ratings
4.0
Product Effectiveness
  • Price per serving : $1.80
  • Key ingredients : L-Phenylalanine, Vitamin B6, Artichoke Leaf Extract, Acetyl L-Carnitine, Coleus Forskohlii
  • Third-party tested : Not specified

Pros and Cons

Pros

  • Improves overall mood and memory function
  • It can help to control cortisol levels to feel less stressed in social situations
  • Suitable for vegans as the capsules are gelatin-free

Cons

  • Some people have reported that the capsules are a bit difficult to swallow

Who is it for?

Who is it for?

  • Vegans and those preferring plant-based ingredients.
  • Individuals needing mood enhancement and stress control.

Who is it not for?

  • People who prefer more traditional, well-established nootropic formulas.

Final Verdict

NeuroFuel offers an effective solution for those seeking vegan-friendly ingredients to enhance mood and cognitive function, making it suitable for a wide range of dietary preferences.

Our tests indicate that this nootropic supplement is excellent for alleviating social anxiety symptoms and boosting overall mental clarity.

The company has kept the formula simple, and all ingredients have scientific backing to support them.

The most interesting one is L-Carnitine, which has been shown to have a big impact on cognitive performance levels [10].

Quick Facts:

How We Tested Best Nootropics for Anxiety

In my role as a health and performance coach, I've seen firsthand how anxiety can impact performance and overall well-being. To find the best nootropics for managing anxiety, we've developed a rigorous testing protocol based on the following key criteria:

Effectiveness

We evaluated the nootropics based on their ability to alleviate symptoms of anxiety as reported by study participants in controlled environments. This included monitoring changes in stress levels, cognitive function, and mood over a set period.

Ingredients

We analyzed the quality and type of ingredients used in each nootropic formula, giving preference to those with natural, clinically proven substances known for their anxiolytic properties.

Price

We assessed the cost relative to the dosage and duration required to see benefits, ensuring that the products offer good value for money without compromising on quality.

Side Effects

It's crucial to consider the potential side effects of nootropics, so we monitored participants for any adverse reactions throughout the testing period.

Bioavailability

We looked at how well the body can absorb and utilize the nootropics, as higher bioavailability can lead to more pronounced and rapid effects.

User Reviews and Testimonials

We scoured forums, blogs, and e-commerce platforms for real user experiences to gauge the reputation and effectiveness of the nootropics among a broader audience.

Buyer’s Guide

A doctor explaining which nootropic to buy

Now let me make a couple of important points to help you make a decision to naturally deal with anxiety.

Who Should Take Nootropics For Anxiety?

Anyone with some form of mild social anxiety should consider taking nootropics.

They can significantly reduce anxiety disorders and stress hormone levels while at the same time improving your brain function for dealing with everyday tasks and situations.

With all-natural ingredients, you also won’t have to worry about nasty side effects that you might get with smart drugs.

Who Shouldn't Take Nootropics For Anxiety?

Anyone with chronic anxiety disorders, obsessive-compulsive disorder, bipolar disorder, or on prescription drugs like anti-anxiety medication shouldn’t take nootropics without first discussing them with a doctor.

While nootropics don’t tend to have adverse effects, they can interact with other drugs and possibly cause high blood pressure.

If you’re dealing with anxiety and depression, then always consult your doctor before taking any supplement.

Ingredients And Dosage

When it comes to the best nootropics for anxiety, it’s important not to just focus on the dosage of ingredients.

Having several different ingredients at a lower dose can often have a much more effective impact.

Here are some of the most important ingredients to watch out for if you’re dealing with social anxiety:

  • Phosphatidylserine
  • Alpha GPC
  • Ginkgo Biloba
  • Rhodiola Rosea
  • Lion’s Mane Mushroom
  • L-Theanine
  • Kanna
  • Cat’s Claw Extract

And most of these you’ll find in the Mind Lab Pro nootropic that made it to the top of our list.

“Rhodiola rosea is an herbal supplement with adaptogen properties that help to provide general resistance to stress. Although its mechanisms of action are not completely understood, it is clear that rhodiola increases resilience to stress at both the cellular and systemic levels.”
- Bill Willis, PhD at Examine.com

FAQs

Does L-Theanine Calm The Mind?

Yes, L-Theanine can help calm the mind and reduce anxiety. It may also help with lowering cortisol levels, and Mind Lab Pro is one of the nootropics that has one of the highest doses available.

Can Nootropics Make Anxiety Worse?

Yes, some nootropics can make anxiety and depression worse, especially if they contain stimulants. You need to be careful to choose one like Mind Lab Pro that can help with reducing anxiety disorder.

What Is the Connection Between Neurotransmitter Imbalances and Anxiety?

Neurotransmitter imbalances can significantly affect mood and are often implicated in anxiety disorders. Certain nootropics can help balance these neurotransmitters, potentially alleviating symptoms of anxiety.

Why Is a Trial-And-Error Approach Important When Using Nootropics for Anxiety?

A trial-and-error approach is important when using nootropics for anxiety because individual neurochemistry varies greatly, which means a nootropic that works for one person may not work for another. A trial-and-error approach allows individuals to find the specific nootropic that best alleviates their unique symptoms of anxiety.

How Do Nootropics Serve as Natural Alternatives to Traditional Anti-anxiety Medications?

Nootropics serve as natural alternatives to traditional anti-anxiety medications by offering natural relief from anxiety with potentially fewer side effects compared to traditional medications. They work by supporting brain health and neurotransmitter balance without the harsh chemicals found in some prescription drugs.

Can Diet Influence the Effectiveness of Nootropics for Anxiety?

Yes, diet can influence the effectiveness of nootropics for anxiety. Certain foods enhance the body's ability to produce these chemicals. A diet rich in nutrients like choline can complement the effects of nootropics, leading to better management of anxiety.

What Roles Do Nootropics Play as Precursors and Adaptogens in Managing Anxiety?

Some nootropics act as precursors, providing the building blocks necessary for the body to produce neurotransmitters associated with mood regulation. Others function as adaptogens, helping the body to maintain neurotransmitter balance and respond to stress more effectively.

Our Verdict on Best Nootropics for Anxiety

Out of all the best nootropics for anxiety, the one our testing team and dietitian highlighted the most is Mind Lab Pro.

It works very well for people dealing with generalized anxiety disorder or social anxiety.

It can also help with preventing panic attacks and lower your stress levels.

And with the boosted mental performance, you’ll find that even busy days at work with lots of people around can be a lot easier to deal with.

Our #1 Recommendation

Mind Lab Pro (Best Overall)

Rated With Total Shape's Scoring System

4.9
Ingredients
4.6
Price
5.0
User Ratings
4.7
Product Effectiveness
Pros
  • Client feedback confirms it works well to reduce anxiety and panic attacks
  • Great choice of ingredients that cross the blood-brain barrier
  • Doesn’t contain stimulants that could impact blood pressure
  • Comes in easy-to-swallow capsules with effects lasting the whole day
  • Get the BEST PRICE until the end of June
Cons
  • You can only buy it directly on the company website and not in stores
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About The Author

James Cunningham, BSc, CPT
Staff Writer & Senior Coach
James Cunningham, BSc, CPT holds a BSc degree in Sport & Exercise Science from University of Hertfordshire. He's a Health & Performance Coach from London that brings a unique blend of academic knowledge of health supplements and practical exercise experience to the table for his readers.
Learn more about our editorial policy
Dr. Kristy June Dayanan, BS, MD is an author with a BS degree from University of the Philippines and an MD from University of Perpetual Help System. Her ability to simplify medical science complexities and dietary supplement jargon for the average reader makes her a valued medical fact checker and reviewer.
Learn more about our editorial policy
Dr. Harshi Dhingra, MBBS, MD is a published peer-reviewed author and renowned physician from India with over a decade of experience. With her MBBS from Bharati Vidyapeeth and an MD from Rajiv Gandhi University, she actively ensures the accuracy of online dietary supplement and medical information by reviewing and fact-checking health publications.
Learn more about our editorial policy

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