Isaac Robertson
Published by Isaac Robertson
Fact checked by Donald Christman, BHSc FACT CHECKED
Last updated: January 20, 2021

Omega XL is popular for two main reasons -- the online raves and Larry King, of all people.

It claims to benefit those who suffer from joint pain and inflammation.

As such, it’s a favorite supplement among older people, which probably explains Larry King’s strange, incongruous promotion of it… Although his face isn’t exactly the most inviting.

Mr. King aside, tons of Omega XL reviews online are mostly positive.

But does it live up to the hype?

Let's get into the details.

*Keep reading till the end to see why we don't recommend Omega XL and what alternative we suggest instead...

What is Omega XL?

Omega XL

Omega XL is a dietary supplement containing over 30 different fatty acids with a range of health benefits and joint pain relief effects. It contains Omega-3 fatty acids including EPA and DHA, all of which are sourced from natural ingredients.

Instead of obtaining these essential fatty acids from fish or algae, which can give a fishy aftertaste, this product sourced them from green-lipped mussels.

Arthritis organizations have recommended these natural ingredients to relieve pain in the joints, especially for older people who may be more sensitive to synthetic products.


According to the Great Healthworks, the Omega XL manufacturer, the main active ingredient in this product is a compound called PCSO-524 (sounds like a Star Wars droid) which is supposedly 89% more effective at reducing joint pain than standard fish oils.

The supplement is intended to be taken 1-2 times a day, depending on your weight. It is always advised to consult your doctor for a proper dosage recommendation, rather than relying solely on reviews.

Celebrities who use this supplement:

Products Similar to Omega XL

Or, you can see our main article on the best omega-3 supplements.

Omega XL Ingredients

omega xl ingredients

So, you’ve read the customer reviews, but what is actually in this product?

  1. PCSO-524 – This ingredient’s full name is Perna Canaliculus Green-lipped Mussel Extract, so I’m quite glad that they shortened it.Because this ingredient doesn’t come from fish, it doesn’t have a fishy aftertaste, which is something that a lot of users seem to like.

    According to a recent study, PCSO-524 is 89% more effective for joint pain relief when compared to regular DHA and EPA fish-based supplements, making it great for joint pain and inflammation.

  2. Omega Fatty Acids – These are known for helping to relieve painful joints, and some studies suggest that they also act as a natural anti-inflammatory, reducing inflammation.
  3. Vitamin E - Vitamin E has numerous health benefits, such as improving skin and nail health. It’s a good addition to this patented oil.
  4. Monounsaturated Olive Oil – ​ Monounsaturated olive oil (i.e. extra virgin olive oil) is known as the healthiest fat on earth, and it’s easy to see why. Better get that extra virgin olive oil in to your diet.

Check out our article on the best Omega 3 supplements.

MUFAs (monounsaturated fatty acids) have been found to lower total cholesterol and low-density lipoprotein (LDL) cholesterol levels. In addition, some research shows that MUFAs may benefit insulin levels and blood sugar control, which can be helpful if you have or are at risk of type 2 diabetes.

- Katherine Zeratsky, Dietitian


Omega XL

Omega XL contains ingredients that help with the treatment of joint pain and inflammation, making it popular with older people who might otherwise use regular fish-based oil to help their bones.

The vitamin E content is also worth noting. Apart from keeping the skin supple and young looking, vitamin E helps reduce joint inflammation.

Elders who are suffering from osteoarthritis typicall lack vitamin E in their diet, so a supplement like Omega XL may be prescribed.

It comes in soft gel capsules, which is something most elders appreciate.

With its target market being on the older side, it makes sense to go with a soft capsule for this supplement.


Some users, in their Omega XL reviews, report improved mobility and reduced joint pain after taking the product. However, there are also some who report that they didn’t feel any difference at all.

  • Extracted from non-animal sources
  • Toxin-free and fights free radicals
  • Improves joint health and can improve mobility
  • Small easy-to-swallow soft capsule
  • Quite expensive
  • Some customer reviews spoke about seeing no effects
  • Quality of ingredients is not established

Side Effects

joint pain

So, what are the side effects of this potent medicine?

Well, there are side effects of having too many Omega-3 (from any source), including high blood sugar, low blood pressure, and diarrhea.

After taking Omega XL, some users reported gaining weight after taking pills. Others also mentioned that it did nothing to improve the mobility of their joints.

However, the effect on pain relief seems to be a common report -- joint pains were reportedly reduced, albeit temporary. Some users also said that it did little for them compared to their usual fish-based supplements.

For better joint pain relief, you can try supplements made for joints instead.

Furthermore, the steep price is a common pain point among users, and there’s no denying that Omega XL is on the expensive side when compared to other supplements out there.

How Much Does Omega XL Cost?

For a 60 capsule bottle, you can find the current most up-to-date price here.


omega xl and muscle pain

Is Omega XL better than fish oil?

This product may be better than fish oil for some users due to its active ingredients, which are sourced from mussels. Unlike fish oil, it contains Perna Canaliculus (PCSO-524), which clinical studies have found to be effective for treating joint pain and inflammation.

Is Omega XL good for your heart?

Omega XL claims to be good for your heart due to the Omega-3 fatty acids that it contains. These healthy fatty acids can help to decrease triglycerides, slightly reduce blood pressure, reduce the risk of blood clotting, and decrease stroke and heart failure risks. It can also help to reduce the risk of problems with an irregular heartbeat.

However, it is worth noting that the body is unable to absorb and make use of omega 3 without other omega fatty acids.

Does Omega XL help arthritis?

It may help with rheumatoid arthritis and other joint problems. This is due to its Omega-3 fatty acids and PCSO-524. Arthritis and other joint problems are also better addressed when omega-3 is paired with omega 7 and 9 fatty acids.

Is Omega XL good for back pain?

This product may be good for back pain. It claims to reduce inflammation in your body, helping to reduce such pains.

However, dietary supplements such as Omega XL are recommended to be consumed as part of a healthy diet and active lifestyle. If you’re looking to specifically target and reduce your back pain, you may want to look for other medicines.

Is Omega XL good for fibromyalgia?

This product may be good for fibromyalgia, as some studies suggest that Omega-3 fatty acids could help reduce symptoms of fibromyalgia if taken at the recommended dosage. However, if you’re suffering from fibromyalgia, you should consult your physician for the best medication, rather than looking solely at reviews.

Omega XL website

Is Omega XL good for lowering cholesterol?

This product may help to lower cholesterol due to its Omega-3 fatty acids content. This is because these fatty acids can effectively reduce bodily inflammation, decrease plaque growth in your arteries, and help to thin your blood. All of these effects combined can indeed reduce your cholesterol, especially if you eat a healthy diet too.

Is Omega XL good for diabetes?

This product may be good for diabetes if taken as part of a recommended healthy diet. For example, researchers found that Omega-3 fatty acids (DHA and EPA), together with Omega-7 and Omega-9 can help to prevent any disease of the liver (ie fatty liver). To be on the safe side, you should always consult your physician about the best medication to take.

Is Omega XL a fat thinner?

No, this is not a fat thinner. Some users report side effects of loose stools and diarrhea, which can lead some people to think that the product is a fat thinner. However, it is primarily formulated for inflammation and joint pain relief in older people.

Is Omega XL approved by the FDA?

No, this product is not approved by the FDA. Many users still find the product to be useful, but the official US Food and Drug Administration has not yet given the product their seal of approval.

Should You Buy Omega XL?

Omega XL may work for people with joint problems who need pain relief. The ingredients are common to many omega-3 supplements, but the user reviews seem to be mixed.

Also, the quality of vitamin E and mussel-based omega-3 is not established, hence some people are quite hesitant with the effectiveness of the product.

If you're on the lookout for a premium omega-3 supplement, I highly recommend OmegaWell from LiveWell Labs instead.

It has a strong dose of EPA and DHA (800 and 600 mg, respectively) -- one of the strongest and most potent in the market today.

It also doesn't contain any preservatives and the ingredients are 100% sustainably-sourced.

OmegaWell by LiveWell Labs

OmegaWell by LiveWell Labs

Our #1 Recommended

  • The added lemon flavor reduces the chance of fishy burps
  • One of the strongest doses of EPA and DHA
  • Available with good bulk-order discounts
  • The small softgels seem to be easy to swallow
  • Get the BEST PRICE until the end of March
Click For Best Price
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